Conserved Protein Domain Family
RING-HC_ITT1-like
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cd23134: RING-HC_ITT1-like 
RING finger, HC subclass, found in Saccharomyces cerevisiae translation termination inhibitor protein ITT1 and similar proteins
ITT1 is a protein that modulates the efficiency of translation termination, resulting in the readthrough of all three types of nonsense codons UAA, UAG and UGA. ITT1 contains a typical C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438496
Aligned: 13 rows
Threshold Bit Score: 76.9744
Created: 11-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #  #              #      #  #  #                  #    #    
Q04638        174 SRSNYHCCICMEMEKGvr-mIKLPCEnanveHYLCRGCAKSYFTAmiqenrisSVRCPQ--CEYKE 236  Saccharomyces cerevisiae S288c
KTB34497      387 NQTSYPCSICMEYFKGsk-cLQLSCS-----HIFCRACLQDFWGLciregeisRVGCPDpeCVKAG 446  Moniliophthora roreri
RKP08906      183 ARTLYPCPVCMEEVRGsd-cLRLACG-----HAFCAGCLTGYFSLmiqegrlaSLQCPSieCQPEP 242  Thamnocephalis sphaerospora
NP_174512     372 LQSLHECCICFSESAGid-fVKLPCQ-----HFFCLKCMKTYTDIhvtegtvnKLKCPDskCGETV 431  thale cress
XP_024378429  325 QESVHTCLICFSEYSGys-fTKLPCQ-----HYFCTTCLKQYCNMhvkegsvlNLNCPDtsCKEQI 384  Physcomitrium patens
EFJ27322      210 LSSIHLCTICFEESTGre-fIKLPCQ-----HAYCRKCMQQYMSVhvtdgsinSLKCPD--CKGGI 267  Selaginella moellendorffii
NP_001237563  281 LKELHDCNICFSEYAGsq-fIRLPCE-----HFFCLKCLQTFAQIhvkegtvsNLKCPEakCAIMI 340  soybean
ETO27706      231 VGPTQLCGVCFDEKPEdg-fYRAPCG-----HNYCIECLETHYRIktqdadvlKVGCIDpnCDREI 290 
TLD28702      193 DRETFDCGICLDPKKGfachRMLDCG-----HVFCVGCLQDFYNNaiqegdisSVRCLTpnCAKDR 253  Pyricularia sp. CBS 133598
TPX65195      213 ENCSFHCGVCLETKPGsqcfRLTACK-----HVFCRECVTNYFTAlitegsvlLVRCPDsrCSKQN 273  Spizellomyces sp. 'palustris'
POW09904      221 DNQDFVCPICLETRKGrqsiQLENCG-----HTFCRNCLQEFFGLmiqegevrKVRCCDegCKQGV 281  Puccinia striiformis
Q9US46        168 QIRKFQCNVCFDEFNGtdcfQLTRCG-----HVSCQSCLRDYYTMciqegmfsQIKCIDldCGKDA 228  Schizosaccharomyces pombe 9...
KAB8416356    171 EQGSYHCSICLDPKPGtvchRMRDCG-----HIFCRECLQDFYSTaitqgevdTVKCIDpdCGKAG 231  Carpinus fangiana

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