Conserved Protein Domain Family
RING-HC_MmTRIM43-like
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cd23133: RING-HC_MmTRIM43-like 
RING finger, HC subclass, found in Mus musculus tripartite motif-containing protein 43 (TRIM43) and similar propteins
This subfamily includes TRIM43A, TRIM43B and TRIM43C, which are expressed specifically in mouse preimplantation embryos. They contain a typical C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438495
Aligned: 4 rows
Threshold Bit Score: 103.067
Created: 11-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #           # #  #  #             #  #           
P86448     11 EETLTCSICQGIFMNPVYLKCGHKFCEACLLLFQEDIkfpaYCPMCMQPFNQEYIND 67   house mouse
P86449     11 EETLTCSICQGIFMDPVYLRCGHKFCETCLLLFQEDIkfpaYCPTCRQPCNQRYIND 67   house mouse
ORY20880  728 KEDITCNICLEIFKNPYTLECGHTFCYSCILLTMKKIs--kKCPICRSIITQKPIVN 782  Neocallimastix californiae
Q3TL54     11 EETLTCSICQSIFMNPVYLRCGHKFCEACLLLSQEDIkfpaYCPMCMQPFNQEYIND 67   house mouse

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