Conserved Protein Domain Family
RING-HC_PRT1-like
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cd23132: RING-HC_PRT1-like 
RING finger, HC subclass, found in Arabidopsis thaliana proteolysis 1 protein (PRT1) and similar proteins
PRT1, also called RING-type E3 ubiquitin transferase PRT1, is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. It functions in the N-end rule pathway of protein degradation, where it specifically recognizes and ubiquitinates proteins with an N-terminal bulky aromatic amino acid (Phe). It does not act on aliphatic hydrophobic and basic N-terminal residues (Arg or Leu) containing proteins. PRT1 contains a typical C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438494
Aligned: 7 rows
Threshold Bit Score: 104.425
Created: 11-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  #            # #  #  #            #  #        
Q8LBL5         22 DQFLCCVCLELLYKP-IVLSCGHLSCFWCVHKSMNgfreSHCPICRDPYVHFP 73   thale cress
XP_003061180    5 EDWHCPVCRDMLCKP-VVNACGHVFCFWCVHRAMDglgtSHCPLCRADYTHLA 56   Micromonas pusilla CCMP1545
XP_024387059    8 EQFQCIICLELVYKP-IVHACGHLFCFWCVHRAMGgthkNLCPLCRRPYMHFP 59   Physcomitrium patens
GAX84645        4 EEWLCPICRDILYKPcVNTTCGHAFCFWCFHHCMNgfrkSSCPLCRSPYANFP 56   Chlamydomonas eustigma
GAQ83276       12 EEYECAICKDLVFKP-AVNVCQHMFCFWCLHQSMNnvseSNCPLCRREYGHLA 63   Klebsormidium nitens
XP_026190405  146 RELTCCICADLLQKP-VLLECGHYFCFWCVYRCMNcydmSVCPLCRTPFDCLP 197  Cyclospora cayetanensis
KFH16679      109 QEFMCSVCLELLWKP-VVLECGHVFCFWCGYQCMNvydvSRCPLCKNAFDKFP 160  Toxoplasma gondii MAS

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