6L8N


Conserved Protein Domain Family
RING-HC_RAD5
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cd23131: RING-HC_RAD5 
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RING finger, HC subclass, found in radiation sensitivity protein 5 (RAD5) and similar proteins
RAD5, also known as revertibility protein 2 (REV2), or DNA repair protein RAD5, is a probable helicase, and a member of the UBC2/RAD6 epistasis group. It functions with the DNA repair protein RAD18 in error-free postreplication DNA repair. It is involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. It may also be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs. It recruits the UBC13-MMS2 dimer to chromatin for DNA repair. RAD5 contains a typical C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438493
Aligned: 7 rows
Threshold Bit Score: 121.782
Created: 11-Jun-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:6L8N; Kluyveromyces lactis RAD5 binds two Zn2+ ions
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #  #               # #  #  #                #  #             
6L8N_A        691 LPSFECAICTTECIEplsaVSITECLHTFCEPCLAEYIEFQQNKklsiNCPYCRMPISEANVLKLK 756  Kluyveromyces lactis NRRL Y...
P32849        909 FQSLECSICTTEPMDld-kALFTECGHSFCEKCLFEYIEFQNSKnlglKCPNCRNQIDACRLLALV 973  Saccharomyces cerevisiae S288C
Q6FY76        892 LIPVECSICTAEPIEss-sAVVTECEHVFCKECLEEYGNFQKEKslqqKCPNCRRDINLNRCLAFE 956  [Candida] glabrata CBS 138
Q6BIP2        911 LKESECSICTQSPIPlg-eMALTPCGHAYCLNCVLEHFDFQEKNsqkpLCPNCREPISKYKIFKLR 975  Debaryomyces hansenii CBS767
XP_028892219  890 IPNSECSICTQSPISvg-eMVVTECGHSFCFHCLKEHIYFQTKNendpLCPDCRGSISIYRLFKLR 954 
Q753V5        827 LKDLECSICTCEAISpltsVVFTRCGHPFCESCLLEYIQFQNKKgsetICPNCRAAVESRYLLKLE 892  Eremothecium gossypii ATCC ...
XP_003686505  914 FIEVECFICIQEPINvm-nVVFTQCGHCFCEDCILSYIKYQIDKksdlKCPICREEISKSSLYRFK 978  Tetrapisispora phaffii CBS ...

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