Conserved Protein Domain Family
RING-HC_MIP1-like
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cd23128: RING-HC_MIP1-like 
RING finger, HC subclass, found in Arabidopsis thaliana MND1-interacting protein 1 (MIP1) and similar proteins
This subfamily includes Arabidopsis thaliana MIP1, RING finger protein 4 (RF4) and RING finger protein 298 (RF298). MIP1 interacts with MND1, HOP2 and XRI1. RF4 and RF298 are putative E3 ubiquitin-protein ligase that may mediate E2-dependent protein ubiquitination. Members of this subfamily contain a typical C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438490
Aligned: 9 rows
Threshold Bit Score: 69.8465
Created: 11-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  #           # #   #  #               #  #          
Q9ZVT8       763 KRERECVMCLSEEmSVIFLPCAHQVLCFKCNQLheke----gmmDCPSCRGTIHRRIQA 817 thale cress
Q8RX22       648 NYDRECIICMKDEvSVVFLPCAHQVVCGSCSDSffasnnggskvTCPCCRGLVQQRIRI 706 thale cress
Q0WPJ7       755 KRERECVMCLSEEmSVIFLPCAHQVLCSKCNQLheke----ameDCPSCRAKIQRRIQA 809 thale cress
XP_002961004 569 RRDRECVMCLCEEiSVVFLPCAHQVVCVKCNDLherk----gmaECPSCRTRIQQRVRV 623 Selaginella moellendorffii
NP_504354    347 KLVAECCICLATKpSIVFMPCRHLITCSGCYDAsd-------frECPTCRSTIENSITV 398 Caenorhabditis elegans
XP_002676945 120 DRERNCIVCMENQrEIVFLQCKHFITCSSCADQl---------rECPICRQSITKSMKV 169 Naegleria gruberi strain NEG-M
KEI71855     112 SSQLECTVCMENDrNVVFAKCHHLVVCGGCAEEl---------kECPVCRGEVKEKSMD 161 Endozoicomonas elysicola
XP_024365280 399 RRDRECVMCMCEEmSVVFMPCAHQVVCIKCNELhekq----gmrDCPSCRTPIQQRIRV 453 Physcomitrium patens
NP_001145490 581 SRRRDCVACKKAAaCVILLQCAHQVLCVGCNKLhedk----gitRCPCCSAEVEERIRV 635 Zea mays

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