Conserved Protein Domain Family
RING-HC_TRAF1-like
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cd23125: RING-HC_TRAF1-like 
RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 1 (TRAF1)-like and similar proteins
TRAF1, also known as Epstein-Barr virus-induced protein 6 (EBI6), is an adapter molecule that regulates the activation of NF-kappa-B and JNK. It plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of an E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This subfamily corresponds a group of TRAF1-like proteins that contains an N-terminal domain with a typical C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438487
Aligned: 6 rows
Threshold Bit Score: 95.6633
Created: 10-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #  #           # #  #  #            #  #     
XP_007474623   48 PEPKYLCCGCHNVLKKAQQTLCGHRYCAACLSWILRisknpICSRCQEENP 98   gray short-tailed opossum
XP_007900918   35 PEEKYLCSFCKNVLKKAHQTLCGHRYCWACVEWIVRcnktpICQKCKEDDP 85   elephant shark
NP_001121853   36 PKDKYLCSNCNNVLNKARQTVCGHRYCLACVNWLVRnnkdlVCTKCKGEDS 86   zebrafish
XP_005987434   34 PEQKYLCCNCKSILKKAQQTFCGHRYCLACLSWLVRnnknpICQKCKEDNP 84   coelacanth
XP_018084995   35 PGEKYLCCSCKNVLKKAQQTLCGHRYCTPCLAWIVRnh--dLCPKCKADDP 83   African clawed frog
OXB67101     1365 PDQKYLCTNCNNVLKKALQTLCGHRYCSACLSWVVRnnknpVCQKCKEEDP 1415 scaled quail

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