Conserved Protein Domain Family
mRING-HC-C3HC3D_arc-1-like
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cd23124: mRING-HC-C3HC3D_arc-1-like 
Modified RING finger, HC subclass (C3HC3D-type), found in Caenorhabditis elegans putative GTP-binding protein trim-23 homolog (arc-1) and similar proteins
arc-1, also called RING-type E3 ubiquitin transferase arc-1, is an E3 ubiquitin-protein ligase that mediates E2-dependent protein ubiquitination. arc-1 contains a modified C3HC3D-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438486
Aligned: 8 rows
Threshold Bit Score: 91.0219
Created: 11-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C DClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other proteins with a C3HC3D-type RING finger with bound Zn2+ ions
  • Comment:modified RING-HC finger (C3HC3D-type)
  • Comment:consensus of the typical C3HC4-type RING-HC finger: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, X is any amino acid and the number of X residues varies in different fingers.
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  #                  # #  #  #               #  #    
Q09654      3 EYGCNVCNEEYSARDPLkcPRVLTGCGHTICHNCAISIAGRNs---sIFCPFDRTAT 56  Caenorhabditis elegans
CDW84690    5 ELTCGLCQRQYSNQGDLi-PRLLPECGHTYCTSCLNTLLSQSeg--eFFCPEDKQNL 58 
Q09623      7 FPECGICGQEYSEDEKLliPRILTECGHTICTGCAGKIKGQSs---iIACPFDRIET 60  Caenorhabditis elegans
NP_496089   3 EYGCNVCNEEYSARDPLkcPRVLTGCGHTICHNCAISIAGRNs---sIFCPFDRTAT 56  Caenorhabditis elegans
POM52157  529 RLECKICLQEYKANVPDltPRILSNCGHTICEGCAVTLLNQNen-gdIACPFDRIVT 584 Caenorhabditis remanei
EGT56351    7 TALCQICQREFTDDDDLv-PRILTECGHSLCTNCAKQILGNQk---kILCPFDRIPT 59  Caenorhabditis brenneri
OZG16852   76 QLECKICLQRYSEDDEDliPRVLTGCGHTLCQKCVGKLMKKSng-frFQCPFDRHST 131 Caenorhabditis latens
EGT51799  128 SIECQICGEHYSDTISSriPRILTECGHTLCHSCAETIQKMSpdqisIKCPIDRIVT 184 Caenorhabditis brenneri

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