Conserved Protein Domain Family
RING-H2_ASR1
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cd23120: RING-H2_ASR1 
RING finger, H2 subclass, found in Saccharomyces cerevisiae alcohol-sensitive RING finger protein 1 (ASR1) and similar proteins
ASR1 is required for tolerance to alcohol. It signals alcohol stress to the nucleus. ASR1 contains a C3H2C3-type RING-H2 finger.
Links
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Statistics
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PSSM-Id: 438482
Aligned: 4 rows
Threshold Bit Score: 93.7571
Created: 15-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #               # #  #  #             #  #         
Q06834       1 MEECPICLADDQEGeqfGCLNVCGHKFHLNCIREWHKys-iNLKCPICRVESTHLEV 56   Saccharomyces cerevisiae S288C
KFM74909  1181 IEDCVICCEEMNFSt--AYKADCGHQFHLTCIREWLNk---KSDCPICRVYLLLPED 1232 Stegodyphus mimosarum
SCU88336     4 SPVCPICLEEMNSGi--GQLTHCGHEYHIDCLRKWHNas-gSLNCPICRVESYILKD 57   Lachancea mirantina
Q75DC2      15 QDECSICWESMPSGv--GRLMPCGHEYHLACIRKWFHlhsgNRSCPVCRTEASVLVD 69   Eremothecium gossypii ATCC 10895

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