Conserved Protein Domain Family
RING-H2_WAVH2
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cd23114: RING-H2_WAVH2 
RING finger, H2 subclass, found in Arabidopsis thaliana protein WAV3 homolog 2 (WAVH2) and similar proteins
WAVH2, also known as RING-type E3 ubiquitin transferase WAVH2, is a probable E3 ubiquitin-protein ligase involved in the regulation of root growth. It acts as a positive regulator of root gravitropism. WAVH2 contains a C3H2C3-type RING-H2 finger.
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Statistics
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PSSM-Id: 438476
Aligned: 5 rows
Threshold Bit Score: 79.1613
Created: 14-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #  #                   # #  #  #                #  #      
Q0WQX9       134 KSNSSRCAICLQRVnsnqsnstaAIFTAECSHSFHLSCVNGLED--------KRCPFCSAAWNH 189 thale cress
CCM10649     371 NTDSEQCSICLNTMgrsd-ciifPSTQIECGHTFHFECIAGYVAnklstypwVRCPNCRNKISE 433 Cardinium endosymbiont of Encar...
XP_024521331  69 RLSRSTCSICLEPMkpg---lghALFTAECSHTFHFSCIASNVRhg-----nLVCPVCRARWKE 124 Selaginella moellendorffii
EDQ91783     116 KALEEECSICLDTMag-----stAVRLLLCHHGFHDECIREHFKt------sQVCPVCMSDLRE 168 Monosiga brevicollis MX1
BAX09103     130 RISKSSCAICLETMkpg---qghAIFTAECSHSFHFQCIASNVRhg-----nLICPVCRAKWKE 185 Japanese cedar

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