3S8V,2JTK,5FWW,3S2K


Conserved Protein Domain Family
Dkk_Cys2
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cd23012: Dkk_Cys2 
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second cysteine-rich (Cys-2) domain of Dickkopf proteins
The Dickkopf (Dkk) family comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the Cys-2 domain of Dickkopf proteins 1- 4.
Links
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Statistics
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PSSM-Id: 437997
Aligned: 17 rows
Threshold Bit Score: 89.3387
Created: 26-May-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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LRP5/6 binding
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:LRP5/6 binding site [polypeptide binding site]
Evidence:
  • Structure:3S2K: Homo sapiens Dickkopf-related protein 1 binds two molecules of LDL receptor-related protein 6, contacts at 4A
  • Comment:Cys-2 domain of the Dkks may enable the proteins to interact with lipids in order to regulate Wnt function
  • Structure:5FWW: Homo sapiens Dickkopf-related protein 1 binds LRP6 and Kremen protein 1; contacts at 4.0A
  • Comment:Kremen protein 1 or Kremen1 (KRM1ECD) is a co-receptor for Dkk proteins
  • Comment:unlike typical Dkks, Dkk3 does not bind LRP5/6
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #     #            #  ## ##        ## ####### #             #       ##       
3S8V_X         4 SGQEGSVCLRSSDCasGLCCARH--FWSKICKPVLKEGQVCTKHRRKGSHgle-------ifQRCYCGEGLSCRIqkdhh 74  human
3S2K_C         8 KGQEGSVCLRSSDCasGLCCARH--FWSKICKPVLKEGQVCTKHRRKGSHgle-------ifQRCYCGEGLSCRIqkdhh 78  human
XP_022079556 167 KLREDEVCEATDQCaqGLCCAQH--FWTRICKPILVEGDVCTKKRDRLTAv----------fQRCHCGDSLSCKRhps-- 232 crown-of-thorns...
NP_001072031 145 PKREKEKCNNTYECadGFCCAQH--GLVKRCKPFLRIGHICPRPRQHHKRspd-------syERCDCEAGLACLAs---- 211 vase tunicate
NP_001091929 157 KARQGEQCSSSVSCedGLCCAQH--LWSKMCKPMLEEGDICTKKRDRLTDv----------fQRCECSQGLSCKRdsv-- 222 purple sea urchin
NP_001158419 135 TGHIGSSCRHENDCmeGLCCAHH--FWERRCKRMLEVDDVCTNDPKPPRMps---------fQRCPCSDGLMCKRdpt-- 201 Saccoglossus ko...
PIK40341      84 KKHHGEDCENSDDCmeGLCCARH--LWSRVCMPMLDEGDLCVKKKDRVSDl----------fQRCDCKSGLSCKRvpd-- 149 Japanese sea cu...
XP_030630798 141 KGEGGDACLRSTDCapGHCCARH--LWTRVCKPELGPGEACTKALQKKGShrv------elfQRCHCSSGLICRVqkeed 212 milkfish
Q9QUN9       201 KGGNGTICDNQRDCqpGLCCAFQrgLLFPVCTPLPVEGELCHDPTSQLLDlitwelepegalDRCPCASGLLCQPhs--- 277 house mouse
RVE68767      75 KGAEMAACVRSGDCaeGLCCVRY--LTGKRCQRIPLEGDACLLRTSTKLKrn---------lGRCACAAGLTCSTrpag- 142 javanese ricefish

Feature 1                               ###   
3S8V_X        75 -----------------qasnsSRLHTCQ 86  human
3S2K_C        79 -----------------qasnsSRLHTCQ 90  human
XP_022079556 233 --------------------pdFRYHTCQ 241 crown-of-thorns starfish
NP_001072031 212 ---------------------tNRHHKCQ 219 vase tunicate
NP_001091929 223 --------------------peRRLHVCQ 231 purple sea urchin
NP_001158419 202 --------------------geTQLHLCQ 210 Saccoglossus kowalevskii
PIK40341     150 --------------------inTRLHACF 158 Japanese sea cucumber
XP_030630798 213 tpnafttgathtamgkataavrARLYTCQ 241 milkfish
Q9QUN9       278 ---------------------hSLVYMCK 285 house mouse
RVE68767     143 ------------------agkhKRQGVCE 153 javanese ricefish

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