Conserved Protein Domain Family
GT_LH1
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cd23004: GT_LH1 
catalytic glycosyltransferase (GT) domain found in lysyl hydroxylase 1 (LH1) and similar proteins
LH1 (EC 1.14.11.4), also called procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1), forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines may serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. LH1 is part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. This model corresponds to the N-terminal conserved domain of LH1, which shows high sequence similarity with catalytic glycosyltransferase (GT) domain of LH3.
Links
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Statistics
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PSSM-Id: 438560
Aligned: 7 rows
Threshold Bit Score: 445.011
Created: 14-May-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Mn binding siteUDP binding
Feature 1:Mn binding site [ion binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens lysyl hydroxylase LH3 (6FXX) binds Mn2+ ion.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                   #  # 
Q02809        26 DNLLVLTVATKETEGFRRFKRSAQFFNYKIQALGLGEDWNVekgt-sagGGQKVRLLKKALEkhaDKEDLVILFADSYDV 104 human
NP_001088279  31 DKLLVLTVATEETDGLRRFQRSAHSFNYKVKVLGLGGQWLG--------EGQKVQLMKLALEpyaDKEDLIILFTESYDV 102 African clawed ...
NP_001071210  29 GDLLVLTVATQETDGFRRFLRSAKHFNYTIKVLGRGETWRGgdymtapgGGQKVRLLKSALEd-iQEEKKVILFVDSYDV 107 zebrafish
XP_005996627  73 ENLLVLTVATKETDGFQRFMRSAKFFNYSIQVLGKGEDWQYghgmnafgGGQKIRLLKSALEeyaDKEDSVILFTESYDV 152 coelacanth
P24802        28 ENLLVLTVATKQTEGFRRFRRSAQFFNYKIQVLGLDEEWKGgddkkpagGGQKVRLLKSALKqhaDKEDLVILFIESYDV 107 chicken
XP_007896042  35 ENLLVVTVATEETDGFKRFFRSAKFFNYTIKVFGLGEEWKGgdvkrtvgGGQKVRILKPALKpyaTREDLVILFVDSYDV 114 elephant shark
RMB91715      28 EKLLVLTVATKQTEGFQRFRRSAQFFNYKVQVLGLDEEWQGgddqqpsgGGQKVRLLKSALKqyvDEEDLIILFIESYDV 107 Hirundo rustica...

Feature 1                                                                                        
Q02809       105 LFAsgPRELLKKFRQArSQVVFSAEELIYPDRRLETKYPvvsdGKRFLGSGGFIGY------APNLSKLVAEWEg----- 173 human
NP_001088279 103 IFAagPGELLKKFRQAkSKVVFSAESVAYPDRHLESKYPvvpeGKRFLGSGGFIGY------AAYLYKMVADWDg----- 171 African clawed ...
NP_001071210 108 IFSsgPKELLKKFQQAkHKVVFSAETLIWPDRHLEDKHPhvreGKRFLGAGGFIGY------AANLKKMLSDWSg----- 176 zebrafish
XP_005996627 153 IFAssPMELLKKFQQTrSRVVFSAETLIYPERRLEVKYPpvldGKRFLSSGGFIGF------APNLNKLVSEWEg----- 221 coelacanth
P24802       108 LFAsgPTELLKKFKQAkSKVVFSAENYIYPDRKLEAKYPpvrdGKRFLGSGGFIGY------APNLKKLVEEWKg----- 176 chicken
XP_007896042 115 IFAsgPEELLKKFQQSrHRVVFAAEAFAWPNRQLEAQYPhvriGKRFLNSGGFIGF------ADNVYQMIEPWSl----- 183 elephant shark
RMB91715     108 LFAsgPAELLKKFKQAkSKVVFSAENYIYPDRKLEAKYPqvrdGKRFLGSGGFIGYapnlkkLVEEWKGQDDDSdqlyyt 187 Hirundo rustica...

Feature 1                                                                                        
Q02809       174 ---QDSDSDQLFYTKIFL---------DPEKREQI----------NITLDHRC--------------RIFQNLDGAL--- 214 human
NP_001088279 172 ---TDKDSDQLFYTKLFL---------DPVKRGKV----------NITLDHRC--------------RIFQNLYGSA--- 212 African clawed ...
NP_001071210 177 ---ADGDSDQLFYTKIYI---------NKEKRKSI----------NITLDSKC--------------RLFQNLHGAL--- 217 zebrafish
XP_005996627 222 ---KDDDSDQLFYTKIFL---------DPEKREKI----------NITLDHKC--------------RIFQNLNGAL--- 262 coelacanth
P24802       177 ---KDDDSDQLFYTKIFL---------DPEKRENI----------NISLDHRS--------------RIFQNLNGAL--- 217 chicken
XP_007896042 184 ---QDDDDDQLFYTKIFL---------DSEKKEKL----------NITLDHRC--------------RIFQNLNGAL--- 224 elephant shark
RMB91715     188 nifLDPEKRMLVFKAIECggnnqppprGCETAECRadseisnlalKYILEHAMlhsteawyglwkqhCKPSNVWCTVqti 267 Hirundo rustica...

Feature 1                                     #             
Q02809       215 ---DEVVLKFEMGHVRARNLAYDTLPVLIHGNGPTKLQLNYLG 254 human
NP_001088279 213 ---EDVVLKFEHGRVRARNLVYDTLPVLIHGNGPTKLHLNYLG 252 African clawed frog
NP_001071210 218 ---DEVVLKFEDGRVRARNVLYDTLPVIIHGNGPTKLQINYLG 257 zebrafish
XP_005996627 263 ---DEVVLKFEDGRVRARNVAYNTLPVIVHGNGPTKLHLNYLG 302 coelacanth
P24802       218 ---DEVVLKFENARVRARNLLYDTLPVIIHGNGPTKLQLNYLG 257 chicken
XP_007896042 225 ---DEVVLKFEDGRVRARNVAYDTLPVIVHGNGPTKLQLNYLG 264 elephant shark
RMB91715     268 qptDEIVLKFENSRVRARNLLYDTLPVVIHGNGPTKLQLNYLG 310 Hirundo rustica rustica

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