Conserved Protein Domain Family
GT_LH2
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cd23003: GT_LH2 
catalytic glycosyltransferase (GT) domain found in lysyl hydroxylase 2 (LH2) and similar proteins
Lysyl hydroxylase 2 (LH2; EC 1.14.11.4), also called procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2), forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. The model corresponds to the N-terminal conserved domain of LH2, which shows high sequence similarity with catalytic glycosyltransferase (GT) domain of LH3.
Links
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Statistics
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PSSM-Id: 438559
Aligned: 5 rows
Threshold Bit Score: 463.529
Created: 14-May-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Mn binding siteUDP binding
Feature 1:Mn binding site [ion binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens lysyl hydroxylase LH3 (6FXX) binds Mn2+ ion.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                   #  # 
O00469        37 DKLLVITVATKESDGFHRFMQSAKYFNYTVKVLGQGEEWRGGdgiNSIGGGQKVRLMKEVMEhyaDQDDLVVMFTECFDV 116 human
XP_007889947  37 ENLLVLTVATKVTDGFKRFMQSAKLLNYTIKVLGEGEEWRGGlafNSIGGGQKVRLLKEEMRkhaDRQDLVVLFTESFDI 116 elephant shark
NP_001082933  33 EKLLVLTVATQETDGFLRFMQSANYFNFNVKVLGMGEEWKGGdvgHSIGGGQKVRLLKEAMEsldQQEDLVVLFVDSYDL 112 zebrafish
XP_006001961  37 ENLLVLTVATKETDGFHRFMQTANYLNYTVKVLGMGEEWKGGevaNAIGGGQKVRLLKEEMSnyaDREDLIVMFIDSYDV 116 coelacanth
XP_018119317  40 DKLLVLTVATRETDGFHRFMQSAKHFSYTVKILGQGIEWKGGdvaHTIGGGQKVRLLKETLEsleEQDDLVILFTDSYDV 119 African clawed ...

Feature 1                                                                                        
O00469       117 IFAggpEEVLKKFQKANHKVVFAADGILWPDKRLADKYPvvhiGKRYLNSGGFIGYAPYVNRIVQQWNlQDNDDDQLFYT 196 human
XP_007889947 117 IFAsgpDELLSKFQRANHKVLFAAESLIWPDKRLAEKYPvvrsGKRFLNSGAFMGYATHLNRIVEQWElQDNDDDQLFYT 196 elephant shark
NP_001082933 113 IFAggaEEILRKFQQSNHKVVFAAEGIIWPDSQLAEKYPsvrsGKRFLNSGGIIGYAPYIQKLVSQWDlHDNDDDQLFYT 192 zebrafish
XP_006001961 117 ILAsgpEELLKKLQQAGHKVIFAAEGLIWPDKRLAEKYPhvrsGKRFLNSGGLIGYAPFINRIVQQWElQDNDDDQLFYT 196 coelacanth
XP_018119317 120 IFAggpEEVLLKFQQSNHKVVFAAEGLIWPDKRLADKYPvvrsGKRFLNSGGFIGYLPYVKQIVQQWNlQDNDDDQLFYT 199 African clawed ...

Feature 1                                                                #             
O00469       197 KVYIDPLKREAINITLDHKCKIFQTLNGAVDEVVLKFENGKARAKNTFYETLPVAINGNGPTKILLNYFG 266 human
XP_007889947 197 KVYLDPSKRVSLNMTLDHKSNIFQNLNGAVDEVELKFENGKARVRNIVYETLPVLIHGNGNTKLLLNYLG 266 elephant shark
NP_001082933 193 KIYVDPIQREKLNMTLDHKCEIFQNLNGALDEVLLKFGTERVRVRNTIYNSLPAVIHGNVNTKVYFNYLA 262 zebrafish
XP_006001961 197 KIYLDPLQRESINITLDHKCRIFQNLNGAVEEVLLKFEKGRVRARNSVYDTLPVVIHGNGPTKIQLNYLG 266 coelacanth
XP_018119317 200 KIYIDQTQRGNINITLDHKSRIFQNINGALDEVILAFEDGKARVRNSQYETLPALIHGNGPTKLQLNYFG 269 African clawed frog

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