7JTK


Conserved Protein Domain Family
DD_CrRSP7-like
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cd22984: DD_CrRSP7-like 
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dimerization/docking (D/D) domain found in Chlamydomonas reinhardtii flagellar radial spoke protein 7 (RSP7) and similar proteins
Flagellar radial spokes contribute to the regulation of dynein arm activity and thus the pattern of flagellar bending. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules. RSP7 is a cAMP-dependent protein kinase (PKA) RII-like protein. RSP7 contains an N-terminal domain which shows high sequence similarity to the dimerization/docking (D/D) domain of regulatory subunit of PKA. The D/D domain of RSP7 heterodimerizes with the D/D domain of RSP11 to form an X-type four-helix bundle within the radial spoke RS1 complex.
Links
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Statistics
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PSSM-Id: 438553
Aligned: 26 rows
Threshold Bit Score: 70.7029
Created: 27-Apr-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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dimer interfaceRSP3 interface
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:7JTK: Chlamydomonas reinhardtii flagellar radial spoke protein 7 (RSP7) and RSP11 form a heterodimer within the radial spoke RS1 complex; contacts at 4A
  • Comment:similar to the dimer of R subunits, the Dimerization/Docking (D/D) domains of RSP7 and RSP11 dimerize to form an X-type four-helix bundle
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               ## # ##   #  #   ##  #    #   #  #   #  
7JTK_M         2 SSTYQKPITIPGDFPAILKAFTREILRAQPsNIYEFGARYFSGLQGQ 48  Chlamydomonas reinhardtii
XP_005822997   2 ASKMRTMHTIPADFPQILKDFTREILRNQPgNIYQFGKEYFAARLRE 48  Guillardia theta CCMP2712
GBF92421       3 SKYQSDALVIPEGFPALLKGFAREVLRAQPsDVYEFGARYFADLAAA 49  Raphidocelis subcapitata
GAQ80608       2 TARYQKQIAVPDGFPILLKDFAREVLRQQPeNIYTFGAQHFQRLHAQ 48  Klebsormidium nitens
KAA6377962     2 SSKYLAPYKIPEGLIKLLKDFTREVLRSQPpNIYVFGEQYFRELFEA 48  Streblomastix strix
CEM09297       2 FSKYAKQFEIPHGLPEVLKGFTREVLRNQPdDIYQFAAEYFDRKAKG 48  Vitrella brassicaformis CCMP3155
KAA6417513     3 TSSSDKRYPIPAALPAILKGFARETLRAQPqDIYKFAAQYFKELNAS 49  Trebouxia sp. A1-2
XP_005783178   2 ASPTAPSFSVPKELPSVLKAFTREVLRANPpDIYGFGAEYFREVVAA 48  Emiliania huxleyi CCMP1516
CBH14566      10 ANRYQPRQHLPPEFPGVLKEYAREVLREQPeDILQWSANYFKRLARE 56  Trypanosoma brucei gambiense DAL972
CUG36939      11 ATRYQQRQALPPNFAQVLKEYTREVLREQPsDVLAWSAQYFKKLALE 57  Bodo saltans

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