Conserved Protein Domain Family
DD_AK8
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cd22979: DD_AK8 
dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 8 (AK8) and similar proteins
AK8 (EC 2.7.4.3/EC 2.7.4.6), also called ATP-AMP transphosphorylase 8, acts as a nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. It has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. It also displays broad nucleoside diphosphate kinase activity. AK8 contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.
Links
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Statistics
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PSSM-Id: 438548
Aligned: 76 rows
Threshold Bit Score: 43.9926
Created: 27-Apr-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q96MA6         9 RIPPEMPQYGEENH-IFELMQNMLEQLLIHQPEDPIPFMIQHLHRD 53  human
KYQ57664      13 IIPPDFVPYMEKHR-LYEFFYELVTQLLIQQPEDPIVFIKQSVQHI 57  Trachymyrmex zeteki
XP_002430652  12 NFPPRFLPYLEKHR-IFELFHECLELLVQNKPRDHVQFLKNILPCA 56  human body louse
KOC65988      12 TLNAQFMAYLEKHR-IYELFHEIATQLVLKRPDDPVVFMKQYLELA 56  Habropoda laboriosa
ERL92898      10 AFPKWHIPYLEKHR-IPELFHELARELLIQKPEDHILFMKQMLQQA 54  mountain pine beetle
XP_015518643  13 IIPPRFVPYMEKHR-IYELFHELATELLIKRPDDHISYLKQCIQHA 57  redheaded pine sawfly
OXU18107      13 MISQKLLSYLEKHR-IFELFQELSMMLLIKKPEDHLLFLKQSIYHA 57  Trichomalopsis sarcophagae
CCW65449      43 VLVADYSRYLEEHPeITEILNDMVLHLLILKPDNPLQEMRSYMQAR 88  Phytomonas sp. isolate EM1
TPP41328     784 ELIIDYTAYLAAHPeITPLLHDIMQHLLLQKPDHPLAAMSEFVRAR 829 Leishmania donovani
ESL07016      25 EVVERNAQYISEHPeITPVLHDILQHLLIHKPEEPLAAIRDYARTR 70  Trypanosoma rangeli SC58
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