Conserved Protein Domain Family
DD_ENO4
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cd22974: DD_ENO4 
dimerization/docking (D/D) domain found in enolase 4 and similar proteins
Enolase (EC 4.2.1.11), also known as phosphopyruvate hydratase, is a metalloenzyme responsible for the catalyzing the conversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP), the ninth and penultimate step of glycolysis. ENO4, also called 2-phospho-D-glycerate hydro-lyase, may be required for sperm motility and function. It contains an N-terminal domain which shows high sequence similarity to the dimerization/docking (D/D) domain of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.
Links
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Statistics
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PSSM-Id: 438543
Aligned: 32 rows
Threshold Bit Score: 94.9217
Created: 29-Apr-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative dimerputative AKAP
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the dimer structures of mammalian RIalpha and RIIalpha D/D domains
  • Comment:The Dimerization/Docking (D/D) domain of R subunits dimerizes to form an X-type four-helix bundle .
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                            #  ##  ##  ##  ## #### ##  # #                 
A6NNW6         14 RELQKLKQQAMEYY-RENDVPRRLEELLNSTFYLQPaDVYGHLANCFSKLAKPPTICKIVGKDVLD 78   human
KOF69144       17 YGRDDLKRQAVEYY-QKNKVPQKIEEVLNNLFYDQPpDIYGYLVNFFQKFALPAIISRVSLGLTNP 81   Octopus bimaculoides
PAA78548       12 HQLHQLKKEAIVYY-QSNGVPLKMEDALNQMFRDRPdCVFGYLSNYFEQLALPPVLSGVRCHKSFD 76   Macrostomum lignano
RDD42360        7 LRDYERKQNAVHYF-KENDVPKRLEELLNKILEDEPeDIFGYMAEHFSQLAKLAVINNIKAEEVYD 71   Trichoplax sp. H2
XP_012560719   24 MNKLELKRLAVKYY-EENKVPQEIENLLNILFLQQPkDLYGYMSDYFGSKSCSPTISEITYQSALS 88   swiftwater hydra
RNA41957      587 RDINELKKQAIQFYtENSDITKRVEDALNNLFYDSPyDVYGYLSEFFAKFSKVPFFTKVSAQKSTL 652  Brachionus plicatilis
TPP65750       15 LTEKQLKAKAIQYY-RENSVLMWIEQVLNKMFLDNPkDMAGYLSEFFTAHAQPPVVASITITKLTS 79   Fasciola gigantica
XP_019848936    8 RVTRELREKAVEYY-SQHDATGALEKLLNKMYIDSPeDMYGYMSEYFHTLSNDPTVSSIEAIELLD 72   Amphimedon queenslandica
TGZ60806        4 KSISELKADIIAYY-SENGVPNVVERALNSMFHHKPgDTNGFMSLYFERLAACPTVSSIHFVNSWN 68   Opisthorchis felineus
KXJ23061       30 QNSLEMKRQAVAYY-SENKVPEHVEKLLNDMFKEKPeDIYGYMSEFFGNISKPPTISKIECHEVLS 94

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