cd22952: arrestin_ART10_N (This model is not part of the current CDD release)
N-terminal arrestin/Vps26-like domain with an immunoglobulin (Ig)-like fold in Saccharomyces cerevisiae arrestin-related trafficking adapter 10 (ART10) and similar proteins
Arrestin-related trafficking adaptors (ARTs) function by targeting specific plasma membrane proteins to the endocytic system. They contain multiple PY motifs that are required for recruitment of Rsp5/Nedd4-like ubiquitin ligase which modifies the cargoes. It has been proposed that ARTs remodel the cell surface in response to environmental cues and may serve as part of a quality-control system at the plasma membrane, targeting damaged and misfolded membrane proteins for ubiquitination and subsequent degradation in the lysosome/vacuole. The family includes a group of uncharacterized proteins similar to Saccharomyces cerevisiae arrestin-related trafficking adapter 10 (ART10), which may regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli. ART10 contains two arrestin/Vps26-like domains, which show Ig-like beta-sandwich folds.
Jiyao W et al.(2023). "The conserved domain database in 2023.",