5IEC,5HCD,5HCC,5HCE


Conserved Protein Domain Family
C5_RaCI-like
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cd22951: C5_RaCI-like 
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Rhipicephalus appendiculatus C5 Inhibitor (RaCI) and similar proteins
This family includes Rhipicephalus appendiculatus C5 inhibitors RaCI1 and RaCI2, Dermacentor andersoni RaCI3, and other homologs. These are novel tick-derived C5 inhibitors that do not share any similarity to previously characterized tick complement inhibitors such as OmCI. Complement C5 activation generates the potent anaphylatoxin C5a and leads to pathogen lysis, inflammation, and cell damage. RaCI binds human C5 and blocks the generation of C5a and membrane attack complex formation. The small size of RaCI compared with OmCI, and their different target sites on C5 (C5d-CUB and C5d-MG1-MG2, respectively), may help define better therapeutic complement 5 inhibitors.
Links
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Statistics
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PSSM-Id: 438569
Aligned: 11 rows
Threshold Bit Score: 96.7513
Created: 13-Oct-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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oligomer
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomer interface [polypeptide binding site]
Evidence:
  • Comment:the structures consist of a quaternary complex C5-OmCI-RaCI-Eculizumab Fab fragment
  • Structure:5HCD: Rhipicephalus microplus RaCI2 interacts with complement 5 subunits; contacts at 4.0A
  • Structure:5HCE: Rhipicephalus appendiculatus RaCI1 interacts with complement 5 subunits; contacts at 4.0A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 ## #          # ## ###         # ##   
5IEC_A      1 XPMEEANTTpi-svKDQCANVTCRRTVDNRGKRHIDGCPpgCLCVLKGPDSkdNLDGTCYLLATTP 65  Rhipicephalus appendiculatus
5HCD_D      1 GPMEEANTTpi-svKDQCANVTCRRTVDNRGKRHIDGCPpgCLCVLKGPDSkdNLDGTCYLLATTP 65  southern cattle tick
5HCC_D      1 GPMSGESQSiq--rKGQCEEVICHRKLNHLGERVTSGCPtgCLCVIREPDNvdNANGTCYALMSST 64  Dermacentor andersoni
5HCE_D      1 GPMEEVKTTpi--pNHQCVNATCERKLDALGNAVITKCPqgCLCVVRGASNivPANGTCFQLATTK 64  Rhipicephalus appendiculatus
AML25524   18 QCYSTAEATlsingGDMCIEKTCNRSIDAAGKKVIAGCPggCLCVFNVSDVtyPANGTCYQLATTT 83  Rhipicephalus appendiculatus
DAA64996   21 CCTSQEPTTpl-kaASQCSNVKCRRRFDHLGNSVTEGCPsgCLCVYQATGYnqEANGTCYELMKTS 85  Hyalomma rufipes
AML25525   19 CYSEEANTTpi-svKDQCANVTCRRTVDNRGKRHIDGCPpgCLCVLKGPDSkdNLDGTCYLLATTP 83  synthetic construct
AML25523   18 HNTEEVKTTpi--pNHQCVNATCERKLDALGNAVITKCPqgCLCVVRGASNivPANGTCFQLATTK 81  Rhipicephalus appendiculatus
DAA64995   21 ECYSSGESQsi-qrKGQCEEVICHRKLNHLGERVTSGCPtgCLCVIREPDNvdNANGTCYALMSST 85  Dermacentor andersoni
DAA64997   21 ECYSSGESQsi-qrKGQCEEVTCHRTLNHLGVAVTSGCPsgCLCVISAPDSavNVNGTCYQLMGST 85  Dermacentor andersoni
AML25526   21 ECYSSGESQsi-qrNGRCEEVTCQRKPNHLGVAVTSGCPpgCLCVIQAPDNavNANGTCYELMTTT 85  synthetic construct

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