3EZH


Conserved Protein Domain Family
NarX_sensor
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cd22900: NarX_sensor 
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ligand binding sensor domain of NarX, and related chemoreceptors
The periplasmic ligand binding sensor domain of NarX is a histidine kinase receptor that responds to nitrate and nitrite to effect regulation of anaerobic respiration in various bacteria and similar proteins. It forms a homodimer and binds to ligands such as nitrate via the dimerization interface, a feature that appears to be conserved in this domain superfamily. NarX-NarL sensor-response regulator pair controls Escherichia coli gene expression in response to nitrate and nitrite. NarX has been shown to exhibit a clear kinetic preference for NarL over NarP, the sensor response partner of NarQ.
Links
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Statistics
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PSSM-Id: 438632
Aligned: 42 rows
Threshold Bit Score: 126.138
Created: 23-Mar-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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ligand bindinghomodimer
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:3EZH: Escherichia coli histidine kinase NarX sensor domain binds a nitrate ion, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     ## ##                                                              
3EZH_A         1 QGVQGSAHAINKAGSLRXQSYRLLAAVPl------sEKDKPLIKEXEQTAFSAELTRAAEr-------DGQLAQLQGLQD 67  Escherichia col...
WP_144387453  68 NSIQGNAHAINRIGYMRMQSFELLSLLPl------nPQKDKVLSAIDKSSHSRFFEDYLHq-------RGLSSEYKKVHT 134 Vibrio algivorus
ABI43288       9 NSLQGSAHAIDEIGSMRMKSYRLLSFLPleneqkllLANSPFISKLNIGKNQLNKGEDVVklkvflerEDLINDFNDLYQ 88  Shewanella sp. ...
KUI99650      41 ESIQGNAHMINQVGAIRMQSYRLLALSNg------qQSIAPDIAVLEHMLEATSFQRFIQh-------EKFETPYLEILQ 107 Vibrio sp. MEBi...
AHN24774      20 NDTKGSAYMINQLGLLRMKSYQLLTIIPl------sPNDYNRLDIFKDLSSSKQYLQLFEh-------YGLTHEFNQLQN 86  Gilliamella api...
WP_110442790  39 NDTKGSAYMINQLGLLRMKSYQLLSMIPv------kQQEYHQLNLFHHFPTSQEYVDILDr-------YQLTEEFDQLKN 105 Frischella perrara
WP_123117247  28 NSIQGSAHAIDEIGSMRMKSYQLLSFVPlsnehkliLKNYVYISELNINHAQSTNFDNLSklmeylerVELIDDFNELHQ 107 Shewanella algae
WP_123016628  41 KSIQGNAHMINRVGAMRMQSYRILAFSEpa----srNQARAEVQRLQAALTAPTFTTFIAd-------EHFVEAYDAILQ 109 Vibrio zhugei
KES17812      39 NETKGSAYMINQLGLIRMKSYQLLSMIPi------eKQHYDQLNIFNDMPSSEQLKLFER--------YHLIAELNQLQS 104 Gilliamella api...
SCC09159      39 NDAKGGAYMVNQLGLLRMKNYQLLTMIPl------nEKEYDRLNIFMDISSSQQHLMILKr-------YNLINEFNQLKI 105 Gilliamella bom...

Feature 1                                                         
3EZH_A        68 YWRNELIPALXRAqnRETVSADVSQFVAGLDQLVSGFDRTTEXRIETAA 116 Escherichia coli K-12
WP_144387453 135 YWLEAVKPNLLIAknPDDVRDIVTQYVAQLDQLVYLIDQETEHRLWILK 183 Vibrio algivorus
ABI43288      89 YWNLQLQPTLLSAktASDARVKVDFFVAKLDNLVKKIDSNTEVKLKLVS 137 Shewanella sp. MR-7
KUI99650     108 LWYSNIKPTLLTSedKDEKLQAVESFIVQLNVLISQIDNHTEHTITTIS 156 Vibrio sp. MEBiC08052
AHN24774      87 EWISNIAPKIQQAkkSDEVKNDIDNYVDLTNNLVHKIDQKTEKQIHYIF 135 Gilliamella apicola
WP_110442790 106 DWFTHILPKLKQAkeIESIRKDIELYVNQIDLVVSKLNNKTEKQLSYIT 154 Frischella perrara
WP_123117247 108 YWSLQLKPSLLAAktSSDARDKVDLFITKLNYLVRKIDKNTETKLELAT 156 Shewanella algae
WP_123016628 110 LWQSDTKNILLSSadSTQKRQAVEALIAKLNVLISQIDQHTENNIRAIA 158 Vibrio zhugei
KES17812     105 LWVTAIAPKIKQAsnIHEIKNEIDDFVAQTDKLVHQIDQKTENQIHYIS 153 Gilliamella apicola SCGC AB-598-I20
SCC09159     106 DWKTQLTTKIKQAqkIDDIKTDIENYVNRINHLVHRIDQKTENKIYYIS 154 Gilliamella bombicola

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