6YUE,5IJI,5JEQ


Conserved Protein Domain Family
NarQ_sensor
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cd22899: NarQ_sensor 
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ligand binding sensor domain of NarQ, and related chemoreceptors
The periplasmic ligand binding sensor domain of NarQ is a histidine kinase receptor that responds to nitrate and nitrite to effect regulation of anaerobic respiration in various bacteria and similar proteins. It forms a homodimer and binds to ligands such as nitrate via the dimerization interface, a feature that appears to be conserved in this domain superfamily. NarQ-NarP sensor-response regulator pair controls Escherichia coli gene expression in response to nitrate and nitrite. NarQ has been shown to interact equally with NarP and NarL response regulators; NarL is the sensor response partner of NarX.
Links
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Statistics
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PSSM-Id: 438631
Aligned: 96 rows
Threshold Bit Score: 124.94
Created: 23-Mar-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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ligand bindinghomodimer
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:5IJI: Escherichia coli nitrate/nitrite sensor histidine kinase NarQ binds a nitrate ion; contacts at 4.0A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     ## ##                                                              
6YUE_A        34 ASSLRDAEAINIAGSLSMQSYRLGYDLQsg--sPQLNAHRQLFQQALHSPVLTNLNVwy--vpEAVKTRYAHLNANWLEM 109 Escherichia col...
5IJI_A        34 ASSLRDAEAINIAGSLRMQSYRLGYDLQsg--sPQLNAHRQLFQQALHSPVLTNLNVwy--vpEAVKTRYAHLNANWLEM 109 Escherichia coli
WP_114337112  46 LQSHSDARAINVSGSLRMQNYRMAYSIEtkapeAEIQAKIVAFEHSLHEPALAKLLDrn--tpPPLKRKYQAILDEWQVL 123 Corallincola sp...
WP_005823334  39 WSNKSDASLINVSGSLRYQSYRFWYEMNha--pENIELRLEEYRASLHSPELQALNSsyl-lpKEVKARYQRLKDVWEEM 115 Actinobacillus ...
WP_111353303  39 WSNHADARLINVAGSLRYQSYRFLHEMEfh--pEIRSSRLAEYQASLNALYEELHSDca---pEKVTQGYQNLKAHWSQM 113 Haemophilus par...
VTR45725      39 WSNKSDAGLINVSGSLRMQSYRFLYEMEhh--pQSIPARLAEYRQSLNSPEIQNSLEhkcllpKEVTEAYAKLQKNWLEM 116 Actinobacillus ...
TXH94505      37 FYSVPDAKAINLSGSLRMQAYRMAYEIEk---dQVVLGRLAQFEQTLHAPELQETQRwi--tpAPLRRTYGEVLLQWQVM 111 Pseudorhodobact...
WP_034612026  34 ISNHSDAEMINVSGSLRMQSYRLLYEMQyq--pALLEQGINTYQTSLQTPTLMNLERfy--vpDSVQSAYRTLLKSWQVM 109 Chelonobacter oris
WP_126599749  34 ASHRSDAELINTTGSLRTQAYQLLYAMEhe-nkQDVQLKMLLHSSTLSATILTDLDRqyf-vpRKIKVGYQEIIKSWTQM 111 Actinobacillus ...
OBX08924      33 LSSQSDAEAINLAGSLRMQAYRLVYQMEhe--pDTISHNLAQYDATLDNNILYQLQNsvv-vpNSVKNAYQDVLRNWQEM 109 Gallibacterium ...

Feature 1                                                 
6YUE_A       110 NNRLSKg-dLPWYQANINNYVNQIDLFVLALQHYAERKMLL 149 Escherichia coli K-12
5IJI_A       110 NNRLSKg-dLPWYQANINNYVNQIDLFVLALQHYAERKMLL 149 Escherichia coli
WP_114337112 124 KAHLTDpakRPLYLAEVKSFVDRIDKLVFLLQSHLEDKVAM 164 Corallincola sp. C4
WP_005823334 116 ALYIRHq-dHESYLSRIEHYVKEIDAFVSALQKFAEFKLKI 155 Actinobacillus minor
WP_111353303 114 ATYIETq-dKRQYLSNIEYYVDEIDTFVKNLQKFAEQKLMI 153 Haemophilus paraphrohaemolyticus
VTR45725     117 ESFIVKr-dRNAYEANIEGYANQVNNFVWQLQEFVELKLKV 156 Actinobacillus pleuropneumoniae
TXH94505     112 REHIENa-tPSRYTDNTEQFVAAIDDFVNQMQYHVEFKVRM 151 Pseudorhodobacter sp.
WP_034612026 110 AGYLRQe-nAEAYRRNLERYVNQVDNFVSVLQQFSEQRIRF 149 Chelonobacter oris
WP_126599749 112 KQYAYEs-nYRLYRSDLKSYVNQIDNFVLLLQKYMDRRNEI 151 Actinobacillus delphinicola
OBX08924     110 EGYVQQn-rIADYQAKVDGYVQKVDHFVVTLQHFSERKIIM 149 Gallibacterium salpingitidis

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