Conserved Protein Domain Family
PlcA-like

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cd22893: PlcA-like 
phospholipase C similar to Legionella pneumophila PlcA
This family includes phospholipase C (PLC) from Legionella pneumophila (PlcA) and Pseudomonas fluorescens (PlcC), and similar proteins. PlcA and PlcC are secreted phosphatidylcholine-hydrolyzing PLCs. PlcC is involved in P. fluorescens's hemolytic activity. Its preferred substrates are 1-palmitoyl-2-arachidonoyl-phosphatidylcholine and dipalmitoyl-phosphatidylcholine. The active enzyme is a monomer that requires calcium and zinc ions for activity.
Statistics
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PSSM-Id: 439192
Aligned: 110 rows
Threshold Bit Score: 124.476
Created: 6-Mar-2020
Updated: 17-Oct-2022
Structure
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Aligned Rows:
 
putative Zn
Feature 1: putative Zn binding sites [ion binding site], 9 residue positions
Conserved feature residue pattern:H D H [QH] H D H H DClick to see conserved feature residue pattern help
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #                                                                          
ABE73153      18 FEGGEHTAIGDDTLlrfvknapai-------------------------------------------------------- 41  Pseudomonas flu...
SFD40899      53 FNADEHKLIVDRGAdkveavgvnfpygmslgknetdyikqfkqakmfavgfdsndfetdfkadnisqdtclddanyrqdi 132 Pseudoalteromon...
SDL55747      23 YNYGEHKAIGDQAFikfvrslqesgr------------------------------------------------------ 48  Pedobacter sp. ...
WP_133780551  58 FVYGEHKIIGDQAFirimknlkanegsatllgy----------------------------------------------- 90  Pedobacter sp. ...
RKY96498      18 GKYGEHREIGNRGFnlaiqnlisshtlgdslkvlkf-------------------------------------------- 53  Ignavibacteriae...
WP_106139452  13 YNYNEHKAIGNAAMsevvnrmmgkgyfvdsltaaqf-------------------------------------------- 48  Spirosoma oryzae
RSL18495      58 WLYPEHRSITFLAIkmlepeqrsqldalwsea------------------------------------------------ 89  Edaphobacter ag...
SFN56653      28 WVYPEHRELALSAVqqldadrrvifdqlwrsa------------------------------------------------ 59  Variovorax sp. ...
KAA0254469    14 WIYPEHRSIAGTAVsglskedraaldalwaea------------------------------------------------ 45  Acidobacteria b...
WP_116848736 204 YEAGEHSQLGDAGDefkkmatpavityivkkgevpeqiakkfgvtvaelkeankd---------kwhiwnknsegfkqgd 274 Deminuibacter soli
Feature 1                                                 #                                      
ABE73153      42 ----------------parqvelhlPNGLALTYGQVIALgGDFYGIpgqpisdg-----nspaervQRFNAAFNSLavlp 100 Pseudomonas flu...
SFD40899     133 hnknlripepeeapekifnipsyvyPNISAFSMGELTALyGDYKMLprcttdsmpllavcflsigaDEYLTLTSLEqnyn 212 Pseudoalteromon...
SDL55747      49 --------------avtflsfsdlkLGGANISYGTLNGLsGDHVGDpy----------------alIELLSDSSSA---- 94  Pedobacter sp. ...
WP_133780551  91 ------mdkivlsqssmyvfprlsaSTLYPTSYGMLNGLsGDHQSDp-------------------VLLEAQLKDPgs-- 143 Pedobacter sp. ...
RKY96498      54 ---feenlgitydtiankyvinsvtFPPNLIAYGELTGLsGDHSTDp------------------lSLEESLRYEFs--- 109 Ignavibacteriae...
WP_106139452  49 ---latqlhlrydaqhqewlfeelsVSPNTISYGDLNGLsGDHESNp-------------------LEMSEQLSYNns-- 104 Spirosoma oryzae
RSL18495      90 -------rhghegrlcaqmgdssngPIPGCIDYAAWPAIaGDHSCSa-------------------QEMLRDVLVApwvp 143 Edaphobacter ag...
SFN56653      60 -------rigneqrlceqgadqtqeLTPSCIDWAALSAIaGDHSCSs------------------qEMMETARSSPwvls 114 Variovorax sp. ...
KAA0254469    46 -------rtgyearlcdtpwaadqgPKPVCVDWSAFPAIaGDHSCSa------------------gQMLQTATESDwi-- 98  Acidobacteria b...
WP_116848736 275 qlviptkiapaikdalndggkfkvnVNGVDVDYGDIIAMsGDMFESp------------------dDLLKMSKAEIe--- 333 Deminuibacter soli
Feature 1                                                                                        
ABE73153     101 as------------------------------------reeaqkILAVMQKEINAVNQAikdgkqpheaydalgdtlsee 144 Pseudomonas flu...
SFD40899     213 psiks-------------------------------dclnekvtQKDYLKHLASGIEAPhgyfgnltsnse--------- 252 Pseudoalteromon...
SDL55747      95 --------------------------------------------LHKIMALHDEYIAMGssaapd--------------- 115 Pedobacter sp. ...
WP_133780551 144 -------------------------------------------vLQKIIALHQEYIDKGlkaapd--------------- 165 Pedobacter sp. ...
RKY96498     110 -------------------------------------------kANKIVRMHDKAKEEFgvaadd--------------- 131 Ignavibacteriae...
WP_106139452 105 -------------------------------------------vLNRIVQLQIQYGQQFlsgapd--------------- 126 Spirosoma oryzae
RSL18495     144 kva----------------------------------aiggtleVKLAAARRRDQRVNAvrhsni--------------- 174 Edaphobacter ag...
SFN56653     115 vadvaaqlkvdlarlpvtaepdmsgrapnvlsdaqrrlagqsvrAQRINALRTADIRLQr-------------------- 174 Variovorax sp. ...
KAA0254469    99 ------------------------------------------lkVAGVSSRLEVAIATAknpiqlrnrl----------- 125 Acidobacteria b...
WP_116848736 334 -------------------------------------------eIVKLIKEEKTTGKAVsserw---------------- 354 Deminuibacter soli
Feature 1                                     #                                                # 
ABE73153     145 wnritgggsavsalvpLGRYLKLAADNADHFGEWA------------------------------------LSAYMAGHT 188 Pseudomonas flu...
SFD40899     253 -----rstdyqytawwGDEMMRLAMVNQNHFSKTG------------------------------------LAVYIGLHR 291 Pseudoalteromon...
SDL55747     116 ----------gklvklDFGYAMLAMKNLSHFYRYGksfqeqlrpfdqaiirqcqrpelvkaafnklnktnaINMYVTLHL 185 Pedobacter sp. ...
WP_133780551 166 ----------aalvgiDLNYALTAAVNLSHFYAYGksftdqlkgfdkekirqacdraylsalvkslsstnaIKMYVSLHL 235 Pedobacter sp. ...
RKY96498     132 ----------vdifniDFTYGLLAVVDESHFYDYGrsfekqirdvqkkhirllelpknveqvfnelektnsIAKYITLHS 201 Ignavibacteriae...
WP_106139452 127 ----------kqllntDFQYGLLALTNFNHFYAYGksltwhlqtvdrqdivdllnpentervfsalkkqnsIRMYVTLHA 196 Spirosoma oryzae
RSL18495     175 -----------dllraDPAYVARAMSNNAHFLLARpntaidpeayls-------------lvlgpgaelnaAGTYTFYHE 230 Edaphobacter ag...
SFN56653     175 ---------------aDTQYATRAGYNNAHFLLARpspnvrpidyas-------------ltlrpgselnaIGVYAWFHL 226 Variovorax sp. ...
KAA0254469   126 ------vksdlelqraDKEYASRAGANNVHFLLARksddprdymle---------------svrnggelnaIGTWIRAHA 184 Acidobacteria b...
WP_116848736 355 ------------dkatKGKFTELAQKNEKHFAPSNaafvpvss---------------------aahggdhKTEWEKFHA 401 Deminuibacter soli
Feature 1                                            #   #     #                                 
ABE73153     189 AALQQavmahq-------tgtdqaLELAYAMNSFADHFLTDLFSAGHLRVPRkqlaav---------------------- 239 Pseudomonas flu...
SFD40899     292 SALEFavkak---------qnaqyWTLAMHYEAAALHSLTDLFAFGHNVVDRsgtsnkilddtnmlniqpvadlmeilhd 362 Pseudoalteromon...
SDL55747     186 VAMDWaaqsgrlkd--qpeqarnlMRFALLFNGFADHFLEDSFSSGHLVVKRtv-------------------------- 237 Pedobacter sp. ...
WP_133780551 236 IAINTaeqsgkmarlgdqngasdlLQAALFLNGVADHFLEDSFSSGHLVVNRtv-------------------------- 289 Pedobacter sp. ...
RKY96498     202 VAINFaeyaghyfh-kdinrsnklLHYALLYSAFADHYLQDAFAAGHLAVHRti-------------------------- 254 Ignavibacteriae...
WP_106139452 197 VAIQLaqqagqfahqqqadkarlyLFYAVLYNAFADHFVEDMCAAGHMVVKRsl-------------------------- 250 Spirosoma oryzae
RSL18495     231 RALGAaariaeghl--speartevALAAFADEAYALHFLQDGFAAGHVVGNW---------------------------- 280 Edaphobacter ag...
SFN56653     227 SALQKasrlrsgal--dsdqrielMRSALADEAFALHFLQDTFAAGHIAGSW---------------------------- 276 Variovorax sp. ...
KAA0254469   185 AAMRLarelasgrv--ppeerpavARRALALEAYGLHFLEDAFASGHVAGTW---------------------------- 234 Acidobacteria b...
WP_116848736 402 KALGLakd--------------gkKNEALLQNAFGDHYLTDAFAAGHLFNKRdlmehfnsqlptsgtgdkrdftaasktf 467 Deminuibacter soli
Feature 1                                                                       #                
ABE73153     240 -------------------------------------------------vtpgeLGSLISRFMHDEDsk--fGLKVRNAm 268 Pseudomonas flu...
SFD40899     363 tgirhdgpsngil-dglnrvtfmegkvvpgyldnsvtrsdqmgylpqvirpylrVRSLGEKDNHDTFnl--qGAWVKNYr 439 Pseudoalteromon...
SDL55747     238 -----------------------------------------------------vASVVNNKALHDFYsa--nGTVVLNRk 262 Pedobacter sp. ...
WP_133780551 290 -----------------------------------------------------lASFTNNKALHDFYse--hGTRVVNRk 314 Pedobacter sp. ...
RKY96498     255 -----------------------------------------------------lGAVIDNKQIHDFYne--aGLKVFNLr 279 Ignavibacteriae...
WP_106139452 251 -----------------------------------------------------aGGITNNKALHDFYnr--iGLQVVNLq 275 Spirosoma oryzae
RSL18495     281 ------------------------------------------------------GTTAVRKGTHDYYne--hGVEVTTWn 304 Edaphobacter ag...
SFN56653     277 ------------------------------------------------------GDASQRQGTHDFYnq--sGLEVFTWs 300 Variovorax sp. ...
KAA0254469   235 ------------------------------------------------------GDVATRKGTHDYYne--fGLDTRTWs 258 Acidobacteria b...
WP_116848736 468 fddvahkawggdlakafselettdfkgvifrpnidsesrfssllqgihlkepdvLESAVVKTLHDDLntmpgGLDVENNm 547 Deminuibacter soli
Feature 1                  #                                                                     
ABE73153     269 --gAQWHAYGDKRYFDsi----------------daDNRVQVKRAVQASADEIFETFIsgiapspaefkap--------- 321 Pseudomonas flu...
SFD40899     440 --gDLFRIYGDGKYNMepvpgep-------vdyiddVSKSVISNAVTASIQSLINAHRyglnavtpgh------------ 498 Pseudoalteromon...
SDL55747     263 --aEIWKAHGDGTFNKpe----------------fiNESARVIEAVELSLSDLWMAYEnaaltqteadfitrip------ 318 Pedobacter sp. ...
WP_133780551 315 --gEIWKAYGDGQFEEk------------------sPDGERIITAVQASLQDLMDAFNtslflgakegfldrvp------ 368 Pedobacter sp. ...
RKY96498     280 --gDEWISFGDGRMDQgtkewrehdtyddlpsdnftKNYRLAIEATKISVEEVFASYIkarkgdeitffesipv------ 351 Ignavibacteriae...
WP_106139452 276 --gTTWKTNGDGFLNIpenkwqtarsfalltkvpvtVKYQRAIEVVSQSLFEVMDAYFdatrtgsatflqtipdsp---k 350 Spirosoma oryzae
RSL18495     305 --gARFVTLGDAFLDP--------------------ESKKRVATAVRDSLAQLANALDgklkiqpnnsetiqpdtf---n 359 Edaphobacter ag...
SFN56653     301 gggNSVVLMGDAHMRA--------------------EDARIASASVKASLEQVLDVVSgrvseavfatladaplqpdafn 360 Variovorax sp. ...
KAA0254469   259 --gSPIVIYGDARMRE--------------------QDRVRTAETVRLSIAQLVESARpgse------------------ 298 Acidobacteria b...
WP_116848736 548 --gDAWPLSGDNTLNA--------------------KTTAIAHKAVAQSQLNIISTLNaatapdi--------------- 590 Deminuibacter soli
Feature 1                                    
ABE73153     322 ----lyvpdlnaaqnpaNNFSPLFKMEG 345 Pseudomonas fluorescens
SFD40899     499 --------vgaeqnfeaIAYLPYWVRYE 518 Pseudoalteromonas denitrificans DSM 6059
SDL55747     319 -eekkmqenyllnnipaLKLVPIPYNSD 345 Pedobacter sp. ok626
WP_133780551 369 -dlkdsqalyliehissLSLVPIPYNSE 395 Pedobacter sp. OK701
RKY96498     352 --ykseyqeffldnykgLSIIPVPFNSN 377 Ignavibacteriae bacterium
WP_106139452 351 rhqadqretfyithfgaLSLVPLPLDSD 378 Spirosoma oryzae
RSL18495     360 tcqethfpsavidkeavEALVPVVAETP 387 Edaphobacter aggregans
SFN56653     361 vcsarnfpsrepgqrvrQADLPLLESTL 388 Variovorax sp. OV329
KAA0254469   299 -------------lgarAEDVPLDVAEA 313 Acidobacteria bacterium
WP_116848736 591 ----------pamqkkvWDYTPHPTTAS 608 Deminuibacter soli

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