6TL0,4B93


Conserved Protein Domain Family
ANKRD27_zf2
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cd22886: ANKRD27_zf2 
Click on image for an interactive view with Cn3D
second Zn-fingernail found in ankyrin repeat domain-containing protein 27 (ANKRD27) and similar proteins
ANKRD27, also called VPS9 domain-containing protein, or VARP, is a multifunctional endosomal protein that acts as a regulatory/accessory factor for retromer-based coats. It may be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and may regulate endosome dynamics. It may also regulate the participation of VAMP7 in membrane fusion events and is involved in peripheral melanosomal distribution of TYRP1 in melanocytes. In addition, ANKRD27 participates in GLUT1 endosome-to-plasma membrane trafficking in a VPS29-dependent manner. ANKRD27 contains two conserved CHPLCxCxxC motifs which are referred to as Zn-fingernails. This model corresponds to the second Zn-fingernail of ANKRD27.
Links
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Statistics
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PSSM-Id: 439266
Aligned: 47 rows
Threshold Bit Score: 48.4747
Created: 4-Mar-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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VPS29 bindingCHPLCxCxxC
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:VPS29 binding site [polypeptide binding site]
Evidence:
  • Structure:6TL0; Homo sapiens ANKRD27 in complex with VPS29, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #######                                            
6TL0_B         20 ADPEFCHPLCQCPKCAPAQKRla-------------kvPASGLGVNVTSQDGSSW 61   human
PAA77563      802 SPSSLCHPLCQCDRCAPLQTAaaasspfdasgrssaapAPPALTVNSASSDGFTL 856  Macrostomum lignano
XP_004992668  902 YAQDKCHPLCQCERCSRMIRAp----------------PGSHITINSQNTDGFTP 940  Salpingoeca rosetta
XP_019713218  687 AEASLCHPLCQCTTCAPAHKAra--------------vPCGALSAKSANADGVTP 727  tiger tail seahorse
XP_022912168  632 FSVNNCHPLCNCEKCFEKNYShnsqs-------islenKKNNLNINSCNPEGYTP 679  Onthophagus taurus
XP_008471939  754 VPDNACHPLCQCAKCKEDVVEses-----------rpvTDECLNINICNSDGYTA 797  Asian citrus psyllid
XP_030223146  704 PSPPLCHPLCQCPACTPNTHKap-------------smQCGGVWVNSANADGFSP 745  Atlantic cod
ROT78021       89 VPKTLCHPLCQCSECAPKSHHnqe-----------npnSFKATSINACNSDGYTP 132  Pacific white shrimp
XP_014220416  744 DSPKFCHPLCNCDKCVSIEELaye------------reNKPPVAINAINSRGETA 786  Trichogramma pretiosum
XP_014616282  547 VRSDLCHPLCCCERCAPMHEYsek------------knKIPAVVFSSYNDNGKTV 589  Polistes canadensis

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