2DYO


Conserved Protein Domain Family
Atg16_NTD
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cd22882: Atg16_NTD 
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N-terminal domain of Saccharomyces cerevisiae autophagy-related protein 16 (Atg16)
Atg16, also called cytoplasm to vacuole targeting protein 11 (CVT11), or SAP18, stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Atg16 interacts with the Atg12-Atg5 protein conjugate through its N-terminal domain (NTD) and self-assembles through its coiled-coil (CC) domain. This model corresponds to the NTD of Saccharomyces cerevisiae Atg16; it does not include the NTD of Atg16 from other organisms.
Links
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Statistics
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PSSM-Id: 439374
Aligned: 3 rows
Threshold Bit Score: 92.1505
Created: 13-Oct-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Atg5 binding
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:Atg5 binding site [polypeptide binding site]
Evidence:
  • Structure:2DYO; Saccharomyces Cerevisiae Atg16 in complex with Atg5, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                           ##   # ### ## ###### #####   #
2DYO_B      2 GNFIITERKKAKEERSNPQTDSMDDLLIRRLTDRNDKEAHLNELFQDNSGAI 53  baker's yeast
A6ZML8      2 GNFIITERKKAKEERSNPQTDSMDDLLIRRLTDRNDKEAHLNELFQDNSGAI 53  Saccharomyces cerevisiae YJM789
NP_013882   2 GNFIITERKKAKEERSNPQTDSMDDLLIRRLTDRNDKEAHLNELFQDNSGAI 53  Saccharomyces cerevisiae S288C

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