4IT3,6QLD,4KR1,6NUW,4JE3,6QLE


Conserved Protein Domain Family
IML3
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cd22875: IML3 
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IML3 domain found in Saccharomyces cerevisiae inner kinetochore subunit IML3 and similar proteins
Increased Minichromosome Loss 3 (IML3) protein, also called CENP-L homolog, constitutive centromere-associated network protein IML3, or minichromosome maintenance protein 19, is a component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. IML3 forms a heterodimer with CHL4. CHL4-IML3 is part of a larger constitutive centromere-associated network (CCAN), also known as central kinetochore CTF19 complex in yeast, which serves as a structural platform for outer kinetochore assembly.
Links
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Statistics
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PSSM-Id: 439373
Aligned: 16 rows
Threshold Bit Score: 221.481
Created: 13-Oct-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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oligomer
Conserved site includes 34 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomer interface [polypeptide binding site]
Evidence:
  • Comment:IML3 is a component of inner kinetochore CCAN-Cenp-A complex.
  • Structure:6QLD; Saccharomyces cerevisiae IML3 interacts with CTF3 and CHL4 within the CCAN-Cenp-A complex, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #                                                                      
4IT3_A         5 PYTWKFLGISKqLSLENGIAKLNQLLNlEVDLDIQTIrvpsdpdggtaadeyIRYEXRLDIsnl--degTYSKFIFLGNs 82  baker's yeast
6QLD_L         1 PYTWKFLGISKqLSLENGIAKLNQLLNlEVDLDIQTIrvpsdpdggtaadeyIRYEMRLDIsnl--degTYSKFIFLGNs 78  Saccharomyces c...
6QLE_L         2 PYTWKFLGISKqLSLENGIAKLNQLLNlEVDLDIQTIrvpsdpdggtaadeyIRYEMRLDIsnl--degTYSKFIFLGNs 79  baker's yeast
XP_001644862   2 PYSWTFYALNEfIDIIKYIDVLEELFGtTITYYVHNLqkgp--------ddsDDANRFKKIelhfefedSQSKVIIIGNd 73  Vanderwaltozyma...
XP_003683868   2 PYAWSFYAVDKyINLEEHYNELEKLFRnSLNIYKNVIeedqdln-sstkntySCFELEYEVig-----dGRFKIMCIENn 75  Tetrapisispora ...
XP_003680600   2 PHVWYFHALNEsVDLKGNLGRLKEFLPgELTLDERDAnn------------aRRTTLIQDRg------eSVSRLVLFNEk 63  Torulaspora del...
XP_004178602   2 LSKWSFFASNRlIEITNETDIPNIEKLfNLKHSIKLLpsns--------sdiVNYELYQYVstspdssvSDFKFFILNQt 73  Tetrapisispora ...
CDH08612       2 HHAWSLFALHKcISLEESLPELGTLLGsPLDLNMSEI---------------DLHCKRIDLkql--lpeGVNQFVAFANt 64  Zygosaccharomyc...
GAV53407       2 RYEWSLFELHRlIILEERFTELKELLGsNLNLDILAI---------------DEHTTRIDLlqe--nddGINRFILFRNs 64  Zygosaccharomyc...
SMN18020       2 SHRWTLYGLDKlIDIEQLDFPEFEDQLdDVVTCTYNDti-----------grDGDEIFHDSmp----sdGMFNLIKLEGt 66  Kazachstania sa...

Feature 1            #                                       ##      # # #                       
4IT3_A        83 k--xEVPXFLCYCGTDn------------------RNEVVLQWLKAEy----GVIXWPIKFe-QKTXIKLADASIvhvtk 137 baker's yeast
6QLD_L        79 k--mEVPMFLCYCGTDn------------------RNEVVLQWLKAEy----GVIMWPIKFe-QKTMIKLADASIvhvtk 133 Saccharomyces c...
6QLE_L        80 k--mEVPMFLCYCGTDn------------------RNEVVLQWLKAEy----GVIMWPIKFe-QKTMIKLADASIvhvtk 134 baker's yeast
XP_001644862  74 s--lDVPAILSHSGDHd-----------------nSGKILIDWFKSEi----DVIIWQLKIn-KKLMIQLADSVIendit 129 Vanderwaltozyma...
XP_003683868  76 d--lEIPMVFCYAGTDe-----------------rYSFIFIEWLKSEi----NCIIWKLQFn-NIQMIDICDTAVspnsf 131 Tetrapisispora ...
XP_003680600  64 k--lEIPTVLAFTGDRd------------------LLAAVLEWLKSVi----GVVMYRITLd-QSMMLAIADAMCggd-- 116 Torulaspora del...
XP_004178602  74 qsniEVPTLIGIFSTDlks-------------ssiHIESLLNWFRLLennsnSPVIWPVMLsdNQLMIDIADSIVknk-- 138 Tetrapisispora ...
CDH08612      65 e--lQIPMVLCYAGDRq------------------AIMLFTSWLKAQ-----GVIVWPLELs-SSTMISIADTMVak--- 115 Zygosaccharomyc...
GAV53407      65 k--mRVPMVLCFAGEDq------------------WIQLFCGWLKSQ-----GVIVLPIELn-AQAMLGIADEIIgl--- 115 Zygosaccharomyc...
SMN18020      67 ---nWQVMIIVPDIKDkergnvqysimsmnfhdetIQRKFLQIFKMMi----GVVLWPLLFn-VDSMINILDSVVdra-- 136 Kazachstania sa...

Feature 1                            ####      ######## ###  #  ##                      # # ###  
4IT3_A       138 en----ieqitwFSSKLYFEPETQ------DKNLRQFSIEIPRESCEGLALGYGntx-----hpYNDAIVPYIYNETGxa 202 baker's yeast
6QLD_L       134 en----ieqitwFSSKLYFEPETQ------DKNLRQFSIEIPRESCEGLALGYGntm-----hpYNDAIVPYIYNETGma 198 Saccharomyces c...
6QLE_L       135 en----ieqitwFSSKLYFEPETQ------DKNLRQFSIEIPRESCEGLALGYGntm-----hpYNDAIVPYIYNETGma 199 baker's yeast
XP_001644862 130 et---dlsnrnwYLTKFVFDVTTTv-----DNNLQKMEFEISKDSCQKLGKNAKh--------pYSEAIIPYIYENTGld 193 Vanderwaltozyma...
XP_003683868 132 nngnfnnidykfYNALFVFDLKTT------DDNLKKMNFEVPASSCRKLFRSNEk--------pFKNSILPYIYEETGik 197 Tetrapisispora ...
XP_003680600 117 ----------rfYDSKFIFDVTTE------DKNLTSMGIEVDKKSLRSLSAGQSr--------pYQESVVPYVYEETGll 172 Torulaspora del...
XP_004178602 139 ----------ywATTKFLFDIQDIat---tNNNLRTISIEIDNQSCSRLYRNQIvkgkndnvsaYRDAIIPYIYENSGil 205 Tetrapisispora ...
CDH08612     116 ----------nyYDTKFVFDIVTH------HKNLKKIEIEIDKQSFRSLAGEKDa--------pLQESIIPYIHDRSGiv 171 Zygosaccharomyc...
GAV53407     116 ----------qsYDTKFIFDVTTT------DRNLRKLELEVDKESFKFLTRNLTlh------taLRDKIVPYIYHRSGmi 173 Zygosaccharomyc...
SMN18020     137 ----------hwYDTVVYFENSRQrdneddERRLAQWSITISKYDCETLIGSSLdn------npYEIIIFPYIEKQTGfh 200 Kazachstania sa...

Feature 1          ##                                       ##
4IT3_A       203 VERLPLTSVILAGHTKIXR---ESIVTSTrslrNRVLAVVLQSIQ 244 baker's yeast
6QLD_L       199 VERLPLTSVILAGHTKIMR---ESIVTSTrslrNRVLAVVLQSIQ 240 Saccharomyces cerevisiae S288C
6QLE_L       200 VERLPLTSVILAGHTKIMR---ESIVTSTrslrNRVLAVVLQSIQ 241 baker's yeast
XP_001644862 194 TIKLPLSSISFTNSCKITEs--NIITIPFsi-kSNLLITFLLETQ 235 Vanderwaltozyma polyspora DSM 70294
XP_003683868 198 TDIIPLNSITLLNHLKITKy--NTITTAFsm-rDNIIHTILKQVQ 239 Tetrapisispora phaffii CBS 4417
XP_003680600 173 LKKLPMASIALLGHARIAK---DTVTTLEddieDKTLSTILESIQ 214 Torulaspora delbrueckii
XP_004178602 206 FDALPIHMINLVNVARIAKdglYQVQDKTp--sIETLILLLSHSQ 248 Tetrapisispora blattae CBS 6284
CDH08612     172 MHKLPLVLIAFAGFATVGM---HVIQTSAw--sSEHLGKLLKCIQ 211 Zygosaccharomyces bailii ISA1307
GAV53407     174 IEKLPLTVISFLGAASVSH---DKIVVSSw--sNESLEKLLELTQ 213 Zygosaccharomyces rouxii
SMN18020     201 LNQLPIKYISLRNYLRISE---NQIRTVRpslsPSILISQLKYVS 242 Kazachstania saulgeensis

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