6KBB,6KBB


Conserved Protein Domain Family
Swc5_NTD
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cd22868: Swc5_NTD 
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N-terminal domain of Saccharomyces cerevisiae SWR1-complex protein 5 (Swc5), and similar proteins
SWR1-complex protein 5 (Swc5) is involved in chromosome stability. It is a component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1, leading to transcriptional regulation of selected genes by chromatin remodeling. This model corresponds to a conserved D/E-rich region at the N-terminus of Swc5, which contains two consecutive DEF/Y motifs (defined here as 5 to 6 D or E residues followed by an aromatic F or Y residue). This region is responsible for the interaction with A-B dimer and participates in the eviction step of H2A-to-H2A.Z exchange reaction.
Links
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Statistics
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PSSM-Id: 439371
Aligned: 6 rows
Threshold Bit Score: 44.9393
Created: 13-Oct-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:trimer interface [polypeptide binding site]
Evidence:
  • Structure:6KBB: Saccharomyces cerevisiae Swc5 in complex with histone H2A-H2B (A-B) dimers; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1      ############### #                                                  
6KBB_F     16 EDEDEDGYIEEEDEDFQPEKDKLgggsddsdasdggDDYDDGVNR--DKGRNKVDYSRIESESGGLIK 81  Saccharomyces cerevisiae S288C
6KBB_E     16 EDEDEDGYIEEEDEDFQPEKDKLgggsddsdasdggDDYDDGVNR--DKGRNKVDYSRIESESGGLIK 81  Saccharomyces cerevisiae S288C
EHN03569   13 EDEEKDGYVEEEDEDFQPERERAggs-------sedEDEDDEHIDk-GKSRSKIDYSRIESESGGLIK 72  Saccharomyces cerevisiae x Sac...
NP_009790  14 EDEDEDGYIEEEDEDFQPEKDKLgggsddsdasdggDDYDDGVNR--DKGRNKVDYSRIESESGGLIK 79  Saccharomyces cerevisiae S288C
P38326     14 EDEDEDGYIEEEDEDFQPEKDKLgggsddsdasdggDDYDDGVNR--DKGRNKVDYSRIESESGGLIK 79  Saccharomyces cerevisiae S288C
Q754T8     17 LEFDEEGYVESEDEDFDPSKPADddke------eelSDKSDGDYQeaDEEAEKYDYSHIESSEGGLVS 78  Eremothecium gossypii ATCC 10895

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