Conserved Protein Domain Family
CYHR1_C
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cd22861: CYHR1_C 
C-terminal domain of cysteine and histidine-rich protein 1 and similar proteins
Cysteine and histidine-rich protein 1 (CYHR1) was first identified as an interaction partner of murine galectin-3. Its biological function is still unknown, but it has been shown to be a prognostic marker for esophageal squamous cell carcinoma and a biomarker in hemodialysis patients for the response to erythropoietin. CYHR1 contains an N-terminal C3HC4-type RING-HC finger. This model represents the conserved C-terminal domain of unknown function.
Links
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Statistics
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PSSM-Id: 439370
Aligned: 32 rows
Threshold Bit Score: 304.262
Created: 6-Mar-2020
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q7YR89       156 DQSHRKEMQLYNSIFSLLSFEKIGYTEVQFRPYRTDDFITRLYYETPRFTVLNQTWVLKARVNDSERNPNLSCKRTLSFQ 235 Bos taurus
XP_013091290 191 DAQRQEEHKLYSDIFSLLSFEKITFNDLQLKPFRTDDFITRLYYETTRFTAFNQQWVIRAKINSDHKNPTHTINRSLSYQ 270 Biomphalaria gl...
XP_784749    195 EAGRDEDTKVLRNVVKLLSYEKINFNDLQLRPYRTDDFITKLYYETSRFSALNQQWVVKARVNDDERNPSHTLERRIAFQ 274 Strongylocentro...
NP_647765    251 DDRIKEEKKMFNTLIDLLSYEKIIFNDLQMKPYRTDEYVHKLFYETARFSAFNQQWVVKARINNSQRDPHQSNERTITYQ 330 Drosophila mela...
ELT87328     182 DAEQGAEIKRYHRLFDLLSYEKITFNDLQLRPYRTDDFITKLYYETSRFSAFNMQWVIKSHVNDSQKSPEKTCKRTLSYQ 261 Capitella teleta
XP_029647424 198 DKQNTEQLKLYEDIFALLSYEKITFNDLQLRPFRTDDFITKLFYETSRFSSFQHQWVLKARVDHDQKDPTHSSKRTLSYQ 277 Octopus sinensis
XP_013410757 194 DESRARETMLFDSIFNLLSFEKITFSDLQLRPYRTDDFITKLFYETSRFTAFNLQWVIKARVNDDIKNPHQTMRRMLSYQ 273 Lingula anatina
XP_027230007 195 AETAEEDSKTFNQIMSVLSFEKITFNDLQLKPYRTDEFIHKLFYETSRFSALGYQWVIKARLNDNQKDPHLTCNRFITYQ 274 Penaeus vannamei
XP_002736139 170 DQIRDDEMKVYSNIFNLLSFEKITLNDLQLRPYRTDDFIPRVYYETSRFSALDQQWVVKGQVNDNHRDPSQSYQRTISYQ 249 Saccoglossus ko...
EFX90213     199 DGNHQEEKKLYGTLFDLLSFEKIAFSDVQLKPYRTDEFIHKLYYETSRFYAFSHQWVIKARINADQKDPTQSSERGISYQ 278 Daphnia pulex

Q7YR89       236 LLLKSKVTA--PLECSFLLLKGPYDDVKISPVIYHFVFTNESNETDYVPLPIv------dSVECNKLLAAKNINLRLFLF 307 Bos taurus
XP_013091290 271 LVAKTKLTA--PMVMHFLALSGPFGGIKMKSKVYNFEFTEEASETEYLDLPId-------SAECNKLLASKTINFRLVMF 341 Biomphalaria gl...
XP_784749    275 LSLKSRITS--NLVMQFMILNGPFSDAKVEPHVYRFEFTPEKTETPYNNIPLi------dSAECNKILASKTINFRVIMF 346 Strongylocentro...
NP_647765    331 LILKTKTST--PMSIHFFALKGPFSDMKVSTQIYKHEFTETSTESEYYVLPLpdgvggsgSSECNRMLANKGINFRLLMF 408 Drosophila mela...
ELT87328     262 LILKSKIEH--PFHVHFLALRGPYGDMQARPAVYEFEFTKESLESPVRDLPVd------gSSECNRLLALKNINMRLILF 333 Capitella teleta
XP_029647424 278 LVLKSRTSN--PLKVLFMALKGPYGDLNVTPYVYEFEFSNDSTESEYHTLPTv------dVLECNKLLASKTINVRLVLF 349 Octopus sinensis
XP_013410757 274 LVLKSKIQA--PIDMYFIALQGPYGETKVRPIIYRHEFSDDSPETDYHILPVi------nSMECNKMLAAKTVNVRLILF 345 Lingula anatina
XP_027230007 275 LIVKSKPSS--PMLVHFMMLRGPFGDMRVDPHICQHEFTESSTESPFFALPLp------dSAECNKLLAARTIDFRLMMG 346 Penaeus vannamei
XP_002736139 250 LVLKSRVGSncNLDVRFIVLKGPFGEMKVKPVIYNYEFTSDKYESDYNLLPLf------tLGECNKLLASKTINCRIIMF 323 Saccoglossus ko...
EFX90213     279 LILKSKATS--PITLYFLMLRGPFGEMQVQPKIYHFEFSESNCESPLVAFPLt------dSAECNKVLSGKAINCRLIMF 350 Daphnia pulex

Q7YR89       308 QIQK 311 Bos taurus
XP_013091290 342 QVTK 345 Biomphalaria glabrata
XP_784749    347 QIPK 350 Strongylocentrotus purpuratus
NP_647765    409 LLNK 412 Drosophila melanogaster
ELT87328     334 QVPK 337 Capitella teleta
XP_029647424 350 LVQQ 353 Octopus sinensis
XP_013410757 346 QVQK 349 Lingula anatina
XP_027230007 347 MVTK 350 Penaeus vannamei
XP_002736139 324 QIQK 327 Saccoglossus kowalevskii
EFX90213     351 MCPK 354 Daphnia pulex
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