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Plasmodium falciparum Venus Flytrap protein PfVFT1 and similar proteins PfVFT1 is a highly immunogenic protein, but its biological role in the Plasmodium falciparum parasite is unknown. It is a parasite-specific antigen expressed by the P. falciparum 3D7 strain in both sexual and asexual stages and was identified as a major candidate for inclusion in a multicomponent blood stage malaria vaccine. Bioinformatic analysis predicts a signal peptide with no identifiable membrane anchors suggesting that it coordinates a membrane-associated partner to enable surface localization. Fractionation of detergent-resistance membranes showed that PfVFT1 clusters with GPI-anchored parasite proteins including Pf38, Pf92, Pf113, PfMSP-1, PfMSP-4, PfASP, and PfRAMA.
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Jiyao W et al.(2023). "The conserved domain database in 2023.",