5Z3G,5SUM,6EM3


Conserved Protein Domain Family
Nsa1_WDR74-like
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cd22850: Nsa1_WDR74-like 
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Ribosome biogenesis protein Nsa1 and similar proteins
Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.
Links
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Statistics
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PSSM-Id: 439302
Aligned: 133 rows
Threshold Bit Score: 188.223
Created: 13-Oct-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:putative rRNA binding site [nucleic acid binding site]
Evidence:
  • Comment:based on the structure of yeast Nsa1 bound to 25S rRNA
  • Structure:5Z3G: Saccharomyces cerevisiae Nsa1 binds to 25S rRNA in the nucleolar pre-60S ribosome; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
5Z3G_V     11 GSIKEVLCNIGTdtsv-------------------------------------qsaLQPFHVAPHLAEGl---------- 43  Saccharomyces cere...
CCA69215   36 GAVKLVNARNIEenda-------------------------------------kssSIKYTLDAQIIPSts--------- 69  Serendipita indica...
KDQ33248   11 GNIKRLHYNPNPsn-----------------------------------------tDDPKTTIKTVLNGst--------- 40  Pleurotus ostreatu...
CEP14418   10 GLIKWISFPPKMeenqrhqkkakk---------------------vegseengskeALQPLTGTFGKVDk---------- 58  Parasitella parasi...
OBZ75240   11 GAVKSIRYTPEEnnk--------------------------------------ewkVESNILVAGGSSGk---------- 42  Grifola frondosa
OMJ07359   10 GLLKCINVKNLNekhedapsnkkqrmkkdeaknvqikqnkkkdkaktasddesastDPGKVTILNGKVSr---------- 79  Smittium culicis
ORZ37834   10 GQLKSIPYGAGTstaiarqqslvpi------------------qpgarsaaefaakAANSQVTTYGNLDk---------- 61  Catenaria anguillu...
PSS06885   11 GAIKTVDYSQNGsk----------------------------------------ewTSSTKVLFQGQEGk---------- 40  Phlebia centrifuga
PVV05279   58 GIVKNRKQVAQEhlss-------------------------------------qkeRTETEVDTNSKSSdtvikiisgtv 100 Smittium megazygos...
THH32102   11 GAIKHITYTQTSe------------------------------------------rWTPLNTTLFAGSSeg--------- 39  Antrodiella citrin...

Feature 1                                                                                     
5Z3G_V     44 --kAYVDRMWVIs-----------------eDEAILARnsGVVELVKIskhlkenealqvdpkgesknekslsddlpkfd 104 Saccharomyces cere...
CCA69215   70 --sRSVQKLAIGtha--------------gkDLVAIAR--ADGSTSVHttenl-------------------------rs 106 Serendipita indica...
KDQ33248   41 -saSSVQALSTSgd----------------sRMVVAAR--ANKTVHVYkwne---------------------------d 74  Pleurotus ostreatu...
CEP14418   59 --eQAIQKLSWAmwe--------------deKVLLVGR--KNGTIQFMspe----------------------------n 92  Parasitella parasi...
OBZ75240   43 --tKAVQKLALQrda-------------ssvTLLTAVR--ADGSSSSYrvke---------------------------d 78  Grifola frondosa
OMJ07359   80 --qHNIEQMELVsidsnnshlffififlcyePQIVVGR--RNGQVDLInas----------------------------t 127 Smittium culicis
ORZ37834   62 --aAGITHLASVhmc--------------grDLVLIAR--KNGTVDVWdhal---------------------------t 96  Catenaria anguillu...
PSS06885   41 --nKAIQKLALSaed-------------dsnTLLAAVR--ADGSTNVFtvn----------------------------- 74  Phlebia centrifuga
PVV05279  101 qreKAIDQLQLAsvt-------------ndnLQLAVAR--RCGSVELIdak----------------------------s 137 Smittium megazygos...
THH32102   40 -kgKAFQKLAAFtqv-------------dsqTLLAAAR--ADGTAVVLavse---------------------------d 76  Antrodiella citrin...

Feature 1                                                                                     
5Z3G_V    105 isEFEITSSVSdlfddakleslssksvkrtkLVDGFVTLCPikkdsSNNTFVAATks------gLLHIIKkgedk--kli 176 Saccharomyces cere...
CCA69215  107 geLVTVSQWREsikrf----------ktdgsNEDNWVGLNIh----PLGIVQSNQr-------gQARLTAle-------- 157 Serendipita indica...
KDQ33248   75 etLEARCSWSEtr----------------mkPETRFVGLAFs----NDTVYSCTSn-------gAFRRTGlp-------- 119 Pleurotus ostreatu...
CEP14418   93 gqILREFKNNHvgv--------------ddeKKGYFVGLFVh----DRYLCACTSt-------gDLSYTPlts------- 140 Parasitella parasi...
OBZ75240   79 ssVDVLHEWTEpr----------------lkSGQRYVGLAMs----ESGIYTCTSn-------gALRLTKlg-------- 123 Grifola frondosa
OMJ07359  128 gnIDSTFSDSLfedkvkl------tfyghhiKNYKYVGLQAn----NTHFISCTNv-------gNIRYQKfd-------- 182 Smittium culicis
ORZ37834   97 gnPELTPLLVSvavyeesem--egktkdemeKMKEVVGLEAl---sDDTFYAVTRt-------gTLSAFTlslyvatsed 164 Catenaria anguillu...
PSS06885   75 seLECEEQWQWket--------------rlrDGQKFVGAAYt----STGVYSCTSn-------gALRLTKlsr------- 122 Phlebia centrifuga
PVV05279  138 gsTISTFEDPIfnekvsi------kinqktiNECFYVGLMTn----DRHFSTCTNlghfrfqpwNLDKSEkp-------- 199 Smittium megazygos...
THH32102   77 geTAETVSEWKetr---------------lkDGQRYVGLSAt----TGGIYSCTSn-------gALRLTQpn-------- 122 Antrodiella citrin...

Feature 1                                                                                     
5Z3G_V    177 klASLGLKAPv--------------EFLQLYDLEdtdtDKYIFAYGGEENLIKLVEIdss-------------------- 222 Saccharomyces cere...
CCA69215  158 -kDTSEVSAFhcn----------vpVNLRHFAATs---TGRHFAYAGTEVNLSVWDSerafrasessng---------ek 214 Serendipita indica...
KDQ33248  120 -eASSADPTPthql-------aalpSNLHAWRMSp---DSETFAYGGDEIDLSVWNVeqafmdrtnlksdn-----ptsk 183 Pleurotus ostreatu...
CEP14418  141 rkDETRTILEl-------------gPNIEIMRGHp--tQTHIFAIGGKERDLCIYDIkaiakskkereeidaagpnknts 205 Parasitella parasi...
OBZ75240  124 -aDESASTSEaas----------lpMRLCDWRLSs---DGNTFAYGGDEVELSVWDAeqaftgtetsvpti-----aesk 184 Grifola frondosa
OMJ07359  183 -fDSLTKSEIedkdqivepftmklgYGMCRMKAQp--dDISKFAVGGVEEDLKIWDInkvkfkpdt-------------- 245 Smittium culicis
ORZ37834  165 etDTMDVVSTtri----------slGGANLDRVRscpgHPHLLALGGKDRDLSILDLnlaldkaapkkgdvrf-nglgve 233 Catenaria anguillu...
PSS06885  123 eaDGGLHSELaa-----------lpMRLAEWRLAp---NQQTFAYAGDEVELSVWDTerafsagpqeagsskn-ndsesk 187 Phlebia centrifuga
PVV05279  200 -eDSDLCGSLpfkm--------klePGLCKMKSQk--hNFNAFAVGGNEQDLKIYDInkvefkkdt-------------- 254 Smittium megazygos...
THH32102  123 -gDDTPAFQLaa-----------lpMRLTEWRLSq---NVETFTYAGDEVEVSVWNTerafaeastsrkpvpt-sedatk 186 Antrodiella citrin...

Feature 1                     #  ###    #                      #                          ####
5Z3G_V    223 ------fqsLKQIWEAKNVKNDRldmRVPVWPMALRFLEPSPGkte-kgKLNYQFAAITRWSHLTKYSTQ------HGRK 289 Saccharomyces cere...
CCA69215  215 rrraekdlfPAELWRAKNVANDNldlRQPVNISSFTFLSREDTgahhsiAVGNTLGAVHRYDTRRGKKPVstw-qdARMS 293 Serendipita indica...
KDQ33248  184 krkrnaqllPGEIWRANNVPNDHlglRQPIRISSLTYLPNTSPhh---lATGTQFGDVRLYDTRAARRPLsnwkifKDGS 260 Pleurotus ostreatu...
CEP14418  206 ihkkksprnVGLIFQAKNVKNDFldlQQPVWIHDLQFVNKEATk----vAVATHYHQFRLYDTKVARRPItn--ieIGKH 279 Parasitella parasi...
OBZ75240  185 krkrvdqliPGEIWRAKNVSNDNlnlRQPVHITALTYLETPTStshnhlVTGTQLGNVRRYDTRAARRPVsdwkgvGKIG 264 Grifola frondosa
OMJ07359  246 -esatnvpsSHAIFIAKNVEHDElglRQPVWITDIAFLNPGTAdtt-kvVTSTGYGQVRIYDTKASKKPVhn--yeILTN 321 Smittium culicis
ORZ37834  234 ptkwngelnPTFVWFAKNLPNDMldlAIPIWITDLRFVNAEGSk----lATCTMYHEVKFYNTATNRRPLav--vyTGDY 307 Catenaria anguillu...
PSS06885  188 krkrseqllSNEIWRAKNLPNDTlnlRQPVRNTAITYLQPSAStsqqhlLVGTQFGDVRRYDTRAARRPVenw-kgVAKV 266 Phlebia centrifuga
PVV05279  255 vcewrspvlKSALFSAKNVPNDYlglRVPVWITDIEFADKKNQtdhskiITSTGYGQIRIYDIRVKKQPVld--iqANDN 332 Smittium megazygos...
THH32102  187 krkrseqllPGEIWRAKNLPNDElnlRHPVRNTALTYLQPSANtsqqhlLVGTQFGDVRRYDTRAARRPVan--wkVGKV 264 Antrodiella citrin...

Feature 1                                                                                     
5Z3G_V    290 PFAQIDllpnrePLSQMEVFDAKgenvvsslgnfqsetFNELNVITTDyk------------------------kNVFKF 345 Saccharomyces cere...
CCA69215  294 GGVSVVe----rGIREHELYVADc--------------ATQLWAIDMRk--------------------------AKEPL 329 Serendipita indica...
KDQ33248  261 GVKTVEa-----GPSNHQIFVSDs--------------QSRLFAVDIR---------------------------NGSVS 294 Pleurotus ostreatu...
CEP14418  280 PIKVLSi-----GTDFNHVLYADt--------------MSTVGMLDIR---------------------------TGKRA 313 Parasitella parasi...
OBZ75240  265 GVSAIEk-----GLSEHEIFVADh--------------GCNLFALDLR---------------------------NGRTI 298 Grifola frondosa
OMJ07359  322 PITNFCi----sKQNDHVMYLTDn--------------TGVVSQIDLR---------------------------TGFTT 356 Smittium culicis
ORZ37834  308 PLRSLSt----iPSRPTEVLASDa--------------KGAIHHISLTkavtefakikqtktnpdnprnrnwnvrQGKPV 369 Catenaria anguillu...
PSS06885  267 GAVGVIe----kGLSEHEIFVSDr--------------GCNLFALDLR---------------------------NGKVA 301 Phlebia centrifuga
PVV05279  333 FINTILl-----AENERDLYFSDn--------------KGGIFQIDLNmalsrratldke---lrlekevdipttENKLN 390 Smittium megazygos...
THH32102  265 GGIGVVe----iGTHEHEAFAADq--------------GTNLYAIDLR---------------------------NGQVT 299 Antrodiella citrin...

Feature 1          ####  #                                                                  
5Z3G_V    346 DgngRMLGKVGRddi------tgsSTYIHVHDGKYLLQGGLDRYVRIFDikTNKMLVKVYvg-sRINFIVMLDDVEIE 416 Saccharomyces cerevi...
CCA69215  330 Y---SYKGISGKi-----------TSITACQSGGYIAAGSLDRYFRLLSsaPANQTSEKGd--lMGHGDVVGKLYITA 391 Serendipita indica D...
KDQ33248  295 Y---GYKGIAGAvssval-sqslmASTSLDRYVRIHSIFAPPLQAGKAQdeKGDVLEKLFv--tSIPTAIVCDEEAML 366 Pleurotus ostreatus ...
CEP14418  314 A---QFKGFTGAatdlvtvplptfDKEKQESEKHCIASASLDRFLRVHEtsTVYRNIEDKaylkQRLTCVLVDEEFEY 388 Parasitella parasitica
OBZ75240  299 Y---GYQGISGAvssla--papslLASASQDRFLRLHSTFPPLLKAGQQdkKGAILDKLYv--kVIPTAVIWDCSPDI 369 Grifola frondosa
OMJ07359  357 S---TYNVSNGKi----------tSMAVVGARGSHLATVGLNRKLIVYRisKKKEIVYQTyl-kQSMTKVLWDDSINI 420 Smittium culicis
ORZ37834  370 V---TRQALIGGfag------aqgAVRHVVTDGKMVIGVGLDRFVRFWDleSHQPRVKFFa--kQRLEACAVWTAGLV 436 Catenaria anguillula...
PSS06885  302 Y---GYKGLAGAvtsiap-spsfvASGADDRFLRLHSTFSLPSAVGEQQeqKGDVLDKLYm--kVTPTAVVWDGKVSA 373 Phlebia centrifuga
PVV05279  391 L---NKKVISIHpg--------avKSLSLMGNDSHLAAVGLDRKLSIYRisGKKNELVVQsymkQRMSAVVYDYSSGF 457 Smittium megazygosporum
THH32102  300 Y---GYKSIAGAvtsvas-sgtylASTAQDRYLRLHSTFPPPSEIGQQQdnKGEVLDKLYv--kSVPTCIVADPSSPR 371 Antrodiella citrinella

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