5AFB,6VHH,5FTT


Conserved Protein Domain Family
Gal_Rha_Lectin_LPHN3
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cd22846: Gal_Rha_Lectin_LPHN3 
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galactose/rhamnose binding lectin domain found in latrophilin-3 and similar proteins
Latrophilin-3 (LPHN3), also called adhesion G protein-coupled receptor L3 (ADGRL3), or calcium-independent alpha-latrotoxin receptor 3 (CIRL-3), or lectomedin-3, is a brain-specific calcium-independent receptor that plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. It is involved in the development of glutamatergic synapses in the cortex. This model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminus of LPHN3.
Links
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Statistics
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PSSM-Id: 438703
Aligned: 9 rows
Threshold Bit Score: 215.735
Created: 4-Jan-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:NAG binding site [chemical binding site]
Evidence:
  • Structure:5AFB: Homo sapiens latrophilin-3 binds N-acetyl-D-glucosamine; contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                        ##               
5AFB_A          9 VVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPD 88   human
6VHH_B          9 VVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPD 88   Homo sapiens
5FTT_C          8 VVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPD 87   house mouse
XP_018096706   33 VVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENTRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPD 112  African clawe...
Q9HAR2         29 VVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPD 108  human
XP_007904122   53 VVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDADPAQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDAFPD 132  elephant shark
XP_014344599   29 VVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDADPAQMENIRCFLPDAFKIMSQRCNNRTQCAVIAGPDVFPD 108  coelacanth
XP_005170999   52 VVRRELSCEGYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENTRCYLPDAYKIMGFRCNNRTQCAVVAGPDVFPD 131  zebrafish
XP_015131944   29 VVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENIRCYLPDAYKIMTQRCSNRTQCAVVAGPDVFPD 108  chicken

Feature 1                           #
5AFB_A         89 PCPGTYKYLEVQYECVPYK 107  human
6VHH_B         89 PCPGTYKYLEVQYECVPYK 107  Homo sapiens
5FTT_C         88 PCPGTYKYLEVQYECVPYK 106  house mouse
XP_018096706  113 PCPGTYKYLEVQYECVPYK 131  African clawed frog
Q9HAR2        109 PCPGTYKYLEVQYECVPYK 127  human
XP_007904122  133 PCPGTYKYLEVQYECVPYI 151  elephant shark
XP_014344599  109 PCPGTYKYLEVQYECVPYI 127  coelacanth
XP_005170999  132 PCPGTYKYLEVQYECVPYK 150  zebrafish
XP_015131944  109 PCPGTYKYLEVQYECVPYK 127  chicken

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