6SKE


Conserved Protein Domain Family
Gal_Rha_Lectin_LPHN2
?
cd22845: Gal_Rha_Lectin_LPHN2 
Click on image for an interactive view with Cn3D
galactose/rhamnose binding lectin domain found in latrophilin-2 and similar proteins
Latrophilin-2 (LPHN2), also called adhesion G protein-coupled receptor L2 (ADGRL2), or calcium-independent alpha-latrotoxin receptor 2 (CIRL-2), or latrophilin homolog 1 (LPHH1), or lectomedin-1, is ubiquitously distributed calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. It is probably implicated in the regulation of exocytosis. This model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminus of LPHN2.
Links
?
Statistics
?
PSSM-Id: 438702
Aligned: 7 rows
Threshold Bit Score: 183.674
Created: 4-Jan-2021
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:putative rhamnose binding site [chemical binding site]
Evidence:
  • Comment:Based on the structure evidence that Mus musculus latrophilin-1 (2JXA) binds rhamnose through its lectin domain.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                #                    #             #                                   # 
6SKE_B          7 VRRELSCEGYSIDLRCPGSDVIMIESANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNRTQCIVVTGSDVFPDP 86   Mus musculus
O95490         36 VRRELSCEGYSIDLRCPGSDVIMIESANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNRTQCIVVTGSDVFPDP 115  human
NP_001177406   36 VRRELSCEGYSIDLRCPGSDVIMIESANYGRTDDKICDADPFQMENTECFLPDAYKIMTQRCNNRTQCIVVTGSDVFPDP 115  chicken
XP_014348444   37 VRRELSCEGYPIDLRCPGSDVIMIESANYGRTDDKICDADPFQMENTDCYLPDAYKIMSQRCNNRTQCIVITGSDVFPDP 116  coelacanth
XP_018116196   36 VRRELACEGYPIDLRCPGSDVIMIESANYGRTDDKICDADPFQMENTDCHLPDAYKIMSQRCNNRTQCIVVTGSDVFPDP 115  African clawe...
XP_007885427   37 VRRELSCEGYPIDLRCPGSDVIMIESANYGRTDDKICDADPFQMENVQCYLPDAFKIMTQRCNNRTQCVVITGSDVFPDP 116  elephant shark
NP_001353776   37 VRRELSCEGYPIDLRCPGSDVIMIETANYGRTDNKICDADPFQMDNINCYLPDAYKIVSQRCNNRTQCVVNTGSDVFPDP 116  zebrafish

Feature 1         ######           
6SKE_B         87 CPGTYKYLEVQYECVPY 103  Mus musculus
O95490        116 CPGTYKYLEVQYECVPY 132  human
NP_001177406  116 CPGTYKYLEVQYECVPY 132  chicken
XP_014348444  117 CPGTYKYLEVQYECVPY 133  coelacanth
XP_018116196  116 CPGTYKYLEVQYECVPY 132  African clawed frog
XP_007885427  117 CPGTYKYLEVQYECVPY 133  elephant shark
NP_001353776  117 CPGTYKYLEVQYECVPY 133  zebrafish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap