Conserved Protein Domain Family
PBD_PPP1R3C
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cd22815: PBD_PPP1R3C 
PP1C binding domain found in protein phosphatase 1 regulatory subunit 3C (PPP1R3C)
PPP1R3C, also called protein phosphatase 1 regulatory subunit 5 (PPP1R5), PP1 subunit R5, or protein targeting to glycogen (PTG), acts as a glycogen-targeting subunit for protein phosphatase 1 (PP1) and regulates its activity. It activates glycogen synthase, reduces glycogen phosphorylase activity, and limits glycogen breakdown. It can dramatically increase basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types. PPP1R3C interacts with the PPP1CC catalytic subunit of PP1 and associates with glycogen. This model corresponds to protein phosphatase 1 catalytic subunit (PP1C) binding domain of PPP1R3C, which contains a RVxF PP1C-binding motif that mediates interactions with PP1C.
Links
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Statistics
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PSSM-Id: 439280
Aligned: 9 rows
Threshold Bit Score: 126.72
Created: 9-Dec-2020
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Download Cn3D
 
putative PP1C
Feature 1:putative PP1C binding site [polypeptide binding site]
Evidence:
  • Comment:RVxF is a PP1C-binding motif.
  • Comment:Based on structure evidence that other family members bind PP1C.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                           ####### # # #######                          
Q9UQK1        51 FVNKLKPLKSCLNIKhkaks---qndwkCSHNQAKKRVVFADSKGLSLTAIHVFSDLPEep--awDLQFDLLDLNDISSA 125 human
Q6DDQ5        31 FVNRFKPLRPCLSLKkesesr--snewnRSKSRNKKRVVFADSKGLSLTSVHVFSEFKDes--slDLQFDLIDLEDITAS 106 African clawed ...
XP_006006373  65 LVNRFKPLRPCISVKsesds---aneelRGPKKTKKKVVFADSKGLSLIAVHVFSEFEEdp--vsDLLFDLGDLEDATAN 139 coelacanth
Q6P950        51 LVNQYKPLRSCISSKteddta--nitwkSPETKAKKKVVFADSKGMSLTAVHVFKEFEEdl--mlDLQFELSDLEDAIVG 126 zebrafish
XP_007894919  51 FANRLKPLRPCISSKneagpc--heewaDSKDKRKKSVVFADDKGLSLTQVNIFSEFEDpl---aDLQFDLTDLEYMTCG 125 elephant shark
XP_007907408  49 SVPRLKPLRPCLNPKsepglggqrwdtrRSRSPGQKRVIFADAKGLSLTAVRVFSEFEDdl---sDLQFELSDLAGCTPG 125 elephant shark
XP_423102     46 FVNRFKPLRPCLHVKrdseaq--ksdwnHSAARAKKRVVFADSKGLSLTAIHTFSEIQEhs--gwDLQFDLIGLENITSN 121 chicken
XP_006002894  31 SVSKLKPLRSCLNQKvassei-pteeweDAKNNMKKKVVFADMKGLSLTAVHIFSDMEDal---pGLHFKFPSLGDTKFT 106 coelacanth
XP_005158565  51 VSNCCKPLRPCLSSRaqlehs--crswqNPKSKTKKKVVFADSKGMSLTAVHVFSTFDNketatsELQFDLEDLEELKNT 128 zebrafish

Feature 1           
Q9UQK1       126 LKH 128 human
Q6DDQ5       107 LKL 109 African clawed frog
XP_006006373 140 LKL 142 coelacanth
Q6P950       127 LKA 129 zebrafish
XP_007894919 126 LKI 128 elephant shark
XP_007907408 126 VSS 128 elephant shark
XP_423102    122 LKL 124 chicken
XP_006002894 107 FRN 109 coelacanth
XP_005158565 129 LHI 131 zebrafish

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