4NDV,4NDS,4NDU,4NDT


Conserved Protein Domain Family
agbl-like
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cd22811: agbl-like 
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alpha-galactosyl binding lectin, and similar proteins
This model includes alpha-galactosyl binding lectin from Lyophyllum decastes, an edible mushroom that has been shown to contain polysaccharide extracts with anti-tumor effects. Lyophyllum decastes lectin (LDL) is a homodimeric protein that recognizes non-reducing alpha-galactosyl groups, with specificity for alpha-1,4-linked galactose (Gal-alpha(1,4)Gal) epitopes. It shows no sequence similarity to any known lectin or other protein of known function, and its structure shows a novel fold. While other mushroom lectins have cytosolic location surmised, the presence of disulfide bridges in LDL suggests that this lectin may be secreted.
Links
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Statistics
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PSSM-Id: 439363
Aligned: 30 rows
Threshold Bit Score: 75.4204
Created: 13-Oct-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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homodimerchemical
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:4NDV: Lyophyllum decastes alpha-galactosyl-binding lectin forms a homodimer; contacts at 4.0A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1      # ######                           # #                  # ##                    
4NDV_A       1 ACWKANSCp-gSAFESkDRLRSFALLYCRYNykppYGQGAFGY----------ASAVSTHGwe-tEAQCINTFEQIITSC 68  Lyophyllum decastes
OJT03653    28 SCYSQSGC---KNCETrDSLESARQAFCGSNdwshSGGISWGW----------AHVTLDGQfa-tQQECWDGFQQVIDQC 93  Trametes pubescens
KKY15354    22 SCYSAGGC---GTCASnDEVWQAREQLCGGDrwksSTSFNWGW----------AVVNLSGRfs-sQQACWDGFENIINQC 87  Diplodia seriata
OJT03636    24 SCYSSGKC---SMCETeDSIWSLHQFFCGSDdwaaAAPVSWGW----------ARATLSGRfa-tQQECWDGFENIIEQC 89  Trametes pubescens
OSC99306    26 TCYSSGGC---QECESrDSIASARQAFCGSSdwnhSNTLNWGW----------ARITLNGRfa-tQQECYDGFENIIDQC 91  Trametes coccinea...
OSC99727   139 DCYSQGGC---QQCESrASMESAKQTFCGSNdwniPGGFGFDWf--------kGRVLLQGTfa-tSQECFDGFENILEQC 206 Trametes coccinea...
PFH49046   108 DCVIKPRC---SACETkDSMDAFVTEYCSQY----WNKFWFQNkg-------aAYVISTPWn--yDFQCENALKNITDSC 171 Amanita thiersii ...
GAD99351    22 TCFPQSGC---GSCASfQQLQDLKNNFCANNwn-vANTPEQFEf--------qSHVQVFGGpigsQSLCEQAFDNIADNC 89  Paecilomyces vari...
KAA8575457  20 QCYNHNEGahkQKCAHkDELAKFADDYCHDH----WSKLNGDWtdfkdrsgntANIGKVANfs-tKAACVAAFSQIVENC 94  Monilinia fructicola
OCL03774    22 TCFPQSGC---KSCASfNQLEDLKNNFCANQfn-tANTIEQFNg--------dAHVQVFGGpigsQSLCSSAFDNIVDDC 89  Glonium stellatum

Feature 1             #          # #       ##
4NDV_A      69 HGQSNGGTLEln----sgRLSLAFGn--CE 92  Lyophyllum decastes
OJT03653    94 LGHKDGGVYNfdfngnsaRLDVGFCn--CE 121 Trametes pubescens
KKY15354    88 YGKKNGGTYDwnyngdsaHLDVNFCt--CR 115 Diplodia seriata
OJT03636    90 YSSKAGGTYDydfdgdaaHLDVSFCt--CE 117 Trametes pubescens
OSC99306    92 YGKKDGGKYTydyngdsaSLDVDFCe--CE 119 Trametes coccinea BRFM310
OSC99727   207 YGNKNGGTYDysfnghtaHLDVDFCn--CN 234 Trametes coccinea BRFM310
PFH49046   172 YDTSRGGVINdag---srHMTLYFCt--CI 196 Amanita thiersii Skay4041
GAD99351    90 YGNHDGGDFNy-------NGTACFCr-rPR 111 Paecilomyces variotii No. 5
KAA8575457  95 YDGWDGGQWVad----glLLSINFCkwsSE 120 Monilinia fructicola
OCL03774    90 FTKQDGGDFNfn----gwDMKLGFCt--CD 113 Glonium stellatum

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