5LRW,5LRU


Conserved Protein Domain Family
OTU_OTUD7B
?
cd22772: OTU_OTUD7B 
Click on image for an interactive view with Cn3D
OTU (ovarian tumor) domain of OTU domain-containing protein 7B
OTU domain-containing protein 7B (OTUD7B) is also called cellular zinc finger anti-NF-kappa-B protein, zinc finger A20 domain-containing protein 1, or zinc finger protein Cezanne. It is a deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that specifically targets Lys11-linked polyubiquitin. It functions as a negative regulator of the non-canonical NF-kappaB pathway by mediating the deubiquitination of TRAF3, an inhibitor of the NF-kappaB pathway, resulting in preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappaB. OTUD7B also deubiquitinates ZAP70, and thus, regulates T cell receptor (TCR) signaling. It belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad. It is classified as a family C64 cysteine protease by MEROPS.
Links
?
Statistics
?
PSSM-Id: 438609
Aligned: 10 rows
Threshold Bit Score: 400.951
Created: 10-Nov-2020
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
polypeptideactive site
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Structure:5LRW: Human Cezanne/OTUD7b OTU domain binds ubiquitin; contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                           ##                                           
5LRW_A        31 QSMLVALEQAGRLNWWvsvdptsQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKeaLKRRWRWQ 110 Homo sapiens
5LRU_A        31 QSMLVALEQAGRLNWWvsvdptsQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKeaLKRRWRWQ 110 Homo sapiens
NP_064590    158 QSMLVALEQAGRLNWWvsvdptsQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKeaLKRRWRWQ 237 human
Q6GQQ9       158 QSMLVALEQAGRLNWWvsvdptsQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKeaLKRRWRWQ 237 human
B2RUR8       158 QSMLVALEQAGRLNWWvsmdstcQRLLPLATTGDGNCLLHAASLGMWGFHDRDLVLRKALYALMEKGVEKeaLRRRWRWQ 237 house mouse
XP_015153835 144 QSMLVALEQAGRLNWWanvdpscQRLLPLATTGDGNCLLHAASLGMWGFHDRDLVLRKSLYTLMDKGVEReaLKRRWRWQ 223 chicken
XP_007884180  48 QSMLVALEQAGRLNWWvhldascQRLLPLATTGDGNCLLHAASLGMWGFHDRDLVLRKALYSMMEKGAEReaLKRRWRWQ 127 elephant shark
NP_001071212 151 QSMMVALEQAGRLNWWtrlgtgcQSLLPLATSGDGNCLLHAASLGMWGFHDRDLMLRKSLYALMDHGQEReaLKRRWRWQ 230 zebrafish
XP_018088953 122 QSMLVALEHAGRLNWWgqldpsyQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKSLYTLMEKGAEKdaLKRRWRFQ 201 African clawed ...
XP_006007683 148 QSMLVALEQAGRLNWWahidascQKLLPLATTGDGNCLLHAASLGMWGFHDRDLVLRKSLYALMDKGVEKeaLKRRWRWQ 227 coelacanth

Feature 1        #     ######       #      #                                      ####           
5LRW_A       111 QTQQNKESGLVYTEDEWQKEWNELIKLASQp---------------------------------GESLEEFHVFVLAHVL 157 Homo sapiens
5LRU_A       111 QTQQNKESGLVYTEDEWQKEWNELIKLASSeprmhlgtngan-----------cggvesseepvYESLEEFHVFVLAHVL 179 Homo sapiens
NP_064590    238 QTQQNKESGLVYTEDEWQKEWNELIKLASSeprmhlgtngan-----------cggvesseepvYESLEEFHVFVLAHVL 306 human
Q6GQQ9       238 QTQQNKESGLVYTEDEWQKEWNELIKLASSeprmhlgtngan-----------cggvesseepvYESLEEFHVFVLAHVL 306 human
B2RUR8       238 QTQQNKESGLVYTEDEWQKEWNELIKLASSeprmhlgsngas-----------gggvesseepvYESLEEFHVFVLAHVL 306 house mouse
XP_015153835 224 QTQQNKESGLVYTEEEWQKEWNELIKLASSeprvhygtnggg-----------cggvesseepvYESLEEFHVFVLAHVL 292 chicken
XP_007884180 128 QTQQNKESGLVYTEDEWRKEWEELMKLASSeprihfnnggngsgrpvastfstmnsgesgeepvYESLEEFHVFVLAHVL 207 elephant shark
NP_001071212 231 QTMQNKESGLVYTEEEWQKEWNELLKLASSeprihystngs-------------sgaesqeepvYESLEEFHVFVLAHVL 297 zebrafish
XP_018088953 202 QTMQNKESGLVYTEEEWQKEWNDLIKLASSeprmhygtnggn-----------cvgvesseepvYESLEEFHVFVLAHVL 270 African clawed ...
XP_006007683 228 QTQQNKESGLVYTEEEWQKEWNELLKLASSeprthygtnggn-----------cgglesseepvYESLEEFHVFVLAHVL 296 coelacanth

Feature 1                  #  #     ##   #                         # #     
5LRW_A       158 RRPIVVVADTMLRDSggEAFAPIPFGGIYLPLEVPasqCHRSPLVLAYDQAHFSALVS 215 Homo sapiens
5LRU_A       180 RRPIVVVADTMLRDSggEAFAPIPFGGIYLPLEVPasqCHRSPLVLAYDQAHFSALVS 237 Homo sapiens
NP_064590    307 RRPIVVVADTMLRDSggEAFAPIPFGGIYLPLEVPasqCHRSPLVLAYDQAHFSALVS 364 human
Q6GQQ9       307 RRPIVVVADTMLRDSggEAFAPIPFGGIYLPLEVPasqCHRSPLVLAYDQAHFSALVS 364 human
B2RUR8       307 KRPIVVVADTMLRDSggEAFAPIPFGGIYLPLEVPasqCHRSPLVLAYDQAHFSALVS 364 house mouse
XP_015153835 293 KRPIVVVADTMLRDSggEAFAPIPFGGIYLPLEVPankCHRSPLVLAYDQAHFSALVS 350 chicken
XP_007884180 208 RRPIVVVADTMLRDSggEAFAPIPFGGIYLPLECPsakCHRSPLVLAYDQAHFAALVS 265 elephant shark
NP_001071212 298 RRPIVVVADTMLRDSggEAFAPIPFGGIYLPLEVPankCHRSPLVLAYDQAHFSALVS 355 zebrafish
XP_018088953 271 KRPIVVVADTMLRDSggEAFAPIPFGGIYLPLEVPpnkCHSSPLVLAYDQAHFSALVS 328 African clawed frog
XP_006007683 297 KRPIVVVADTMLRDSggEAFAPIPFGGIYLPLEVLeskCHSSPLVLAYDQAHFSALVS 354 coelacanth

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap