Conserved Protein Domain Family
OTU_fungi_OTU2-like
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cd22762: OTU_fungi_OTU2-like 
OTU (ovarian tumor) domain of fungal OTU domain-containing protein 2 and similar proteins
This subfamily includes Schizosaccharomyces pombe and Saccharomyces cerevisiae OTU domain-containing protein 2 (OTU2) and similar proteins. S. pombe OTU2 is a ubiquitin thioesterase/hydrolase (EC 3.4.19.12) that can remove conjugated ubiquitin from protein substrates and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Fungal OTU2 bbelongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad.
Links
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Statistics
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PSSM-Id: 438599
Aligned: 31 rows
Threshold Bit Score: 157.389
Created: 7-Oct-2020
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putativeactive site
Feature 1:putative polypeptide substrate binding site [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         #                                                              
P38747       161 LCELKKLKQFDIQPDGHCLFASILDQLKlrhdpk------------------kldqdmDVMKLRWLSCNYVQEHRDDFip 222 Saccharomyces c...
XP_004181695 103 KLAKLQMKEHDVKPDGHCLFASILHQLQindlv--------------------netndDIYKLRGLIGDHILANKDDFlp 162 Tetrapisispora ...
XP_030751177 663 LVRDENLQIHPIRPDGSCLFAAVGHQLQlkgm-----------------------ptyTPTEIRKKAANYLRQNKPRFmh 719 rice weevil
XP_009497288 190 LLSQAGLSLFEIRPDGHCLFNAVDHQYShvfg----------------------qtlrGPNHWRRFACDWMRQHRDHFqh 247 Fonticula alba
VBB75124     199 VLKREGLEEVEVRADGHCLFAAVGDQLFrrgvt---------------------eellDYREVRRRAAEYMDRNRDDFep 257 Podospora comata
OBA28749     179 RCENLELKQEEIKADGHCLYYSILDQLQqrhsasmfsdyaipksfkffnepeafyenlNIQTLRQLNVSYLRENKEKYef 258 Hanseniaspora v...
KKA01849     167 KFEELNVVLEEIKADGNCLFYSVVNQLKarhshelfntynipekfeyfenadlfydklSQKLLRELVVCYLQENKESFqf 246 Hanseniaspora u...
XP_001644537 159 YCLEHKFVQYDIKPDGHCLFASILDQLTisinnsn-----------------nkiqynDVSELRKLSCEYVDKNRDDFip 221 Vanderwaltozyma...
XP_003685013 150 FLQQNGFVESEVKPDGHCLFASVLDQLRvldlvv-------------------pevsaSVQQLRSVACRYIQANKDNFip 210 Tetrapisispora ...
XP_024663887 110 KIAGDGLEVFEIEADGHCLFASIADQLDqrms-----------------------lvvDVKTLRSKAAEHIRKHPKEFas 166 Wickerhamiella ...

Feature 1                                  #  #      ####                            # #         
P38747       223 ylfd-----------eetmkMKDIDEYTKEMEHtAQWGGEIEILALSHVFDCPISILMSGr-----PIQVYNEcg----- 281 Saccharomyces c...
XP_004181695 163 yl---------------ideGDDINSYVKSIKEtAKWGGDVEIMAVCQLYDCQVCIMMSEq----qDPIVFNDkg----- 218 Tetrapisispora ...
XP_030751177 720 vlvqeadlvdknsggsrrtaDQAYEAYCVRVET-DRWGGHTEIIALANVFACVINVIQTPg-----RFLCMVPyea---- 789 rice weevil
XP_009497288 248 fam------------nedgeVTDFDEYLETMEHtAVWGGHPELFALASATGTPIHVFQAPs-----KVATFGDlsgskll 310 Fonticula alba
VBB75124     258 fv---------------dleSQSWEEYLRKIRDtSAWGGQPELLALARVFGVGITVVQVP------RNEVINReg----- 311 Podospora comata
OBA28749     259 ilfd-----------estdeLQDFDKYCEKMENtAAWGGEIELSIFSKIFNSKIFILQEN------SQYYIGDdsd---- 317 Hanseniaspora v...
KKA01849     247 llfn-----------eetdqLYDFDEYCTMMKDtSAWGGEVELSIISEIFRCKIFVLQQD------SSFEIGNtal---- 305 Hanseniaspora u...
XP_001644537 222 fmfd-----------ettgdLKDLDEYIKEISEtAKWGGEIELLSLSKSLNVTIKVVMANlnnnsiNFHIINEsdd---- 286 Vanderwaltozyma...
XP_003685013 211 fmfd-----------ertgeLNDIDEYVREMEStAKWGGELELLALSKSLNVTINVLVSDlssnstRFQKYNDaqdp--- 276 Tetrapisispora ...
XP_024663887 167 flld-----------ektgeLIDIDTYCDTLENtAMWGGEIEIQALSEVFSTPIKVYFASq-----PVMTVNEea----- 225 Wickerhamiella ...

Feature 1                                     #        ###    
P38747       282 ---------------------knPELKLVYYKHSYALGEHYNSLH 305 Saccharomyces cerevisiae S288C
XP_004181695 219 ----------------------kNVINLVYFKHYYSLGEHYNSIY 241 Tetrapisispora blattae CBS 6284
XP_030751177 790 --------------------sdnPELTIVFHQKMFAAGGHYNSTV 814 rice weevil
XP_009497288 311 eaaaeagalvvispdegvprsgkPALSLVYQRHTLGLGEHYNSTL 355 Fonticula alba
VBB75124     312 ---------------------ggKMLWVVYYWKGSNSGRHYNSLK 335 Podospora comata
OBA28749     318 --------------------fknPELKLIYYKHTFTLGEHYGSLR 342 Hanseniaspora valbyensis NRRL Y-1626
KKA01849     306 ---------------------tnPTLKLVYYKHTLALGEHYASLI 329 Hanseniaspora uvarum DSM 2768
XP_001644537 287 --------------------nslDVLNLVYYKHSYSLGEHYNSLR 311 Vanderwaltozyma polyspora DSM 70294
XP_003685013 277 -------------------atdtRDIYIVYYKYNYTLGEHYNSLH 302 Tetrapisispora phaffii CBS 4417
XP_024663887 226 ---------------------agEPLFLAYYTKIFGLGAHYNSLR 249 Wickerhamiella sorbophila

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