2W3O,1UJX,1YJ5,1YJM,2BRF


Conserved Protein Domain Family
FHA_PNKP
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cd22736: FHA_PNKP 
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forkhead associated (FHA) domain found in bifunctional polynucleotide phosphatase/kinase (PNKP) and similar proteins
PNKP (EC 3.1.3.32/EC 2.7.1.78), also called DNA 5'-kinase/3'-phosphatase, or polynucleotide kinase-3'-phosphatase, plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNKP ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. PNKP contains an FHA domain at its N-terminus. The FHA domain is a small phosphopeptide recognition module.
Links
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Statistics
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PSSM-Id: 438788
Aligned: 10 rows
Threshold Bit Score: 166.884
Created: 7-Sep-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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phosphopeptide
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:phosphopeptide binding site [polypeptide binding site]
Evidence:
  • Structure:2W3O; Homo sapiens PNKP in complex with XRCC1-derived phosphopeptide through its FHA domain, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                  ###  ### #####                    ###                 
2W3O_A        12 RLWLESPPgeaPPIFLPsDGQALVLGRGPLTQVTDRKCSRTQVELVADPEtRTVAVKQLGVNPSTTGTQELKPGLEGSLG 91  Homo sapiens
1UJX_A        16 RLWLQSPTggpPPIFLPsDGQALVLGRGPLTQVTDRKCSRNQVELIADPEsRTVAVKQLGVNPSTVGVQELKPGLSGSLS 95  Mus musculus
1YJ5_C         9 RLWLQSPTggpPPIFLPsDGQALVLGRGPLTQVTDRKCSRNQVELIADPEsRTVAVKQLGVNPSTVGVHELKPGLSGSLS 88  Mus musculus
1YJM_A         9 RLWLQSPTggpPPIFLPsDGQALVLGRGPLTQVTDRKCSRNQVELIADPEsRTVAVKQLGVNPSTVGVHELKPGLSGSLS 88  Mus musculus
2BRF_A         9 RLWLESPPgeaPPIFLPsDGQALVLGRGPLTQVTDRKCSRTQVELVADPEtRTVAVKQLGVNPSTTGTQELKPGLEGSLG 88  Homo sapiens
Q96T60         9 RLWLESPPggaPPIFLPsDGQALVLGRGPLTQVTDRKCSRTQVELVADPEtRTVAVKQLGVNPSTTGTQELKPGLEGSLG 88  human
NP_001071046   2 QCTLVSVDg--DRVVLP-DGRALMFGRGPESRISDKKCSRHQVKLVADYAkQEVLVTQLGPNPSSLDGQCLGRGESGCLT 78  zebrafish
NP_001108303   2 KCFLRSVDgkhGPIALP-EGKGVTIGRGPETLITDRKCSKTQVELVANLEsRAVRVTQLGANPCSVGEALLKKGESILMK 80  African clawed ...
XP_005990984   2 ECFLISVDkqhDPIPLL-DDTPVILGRGPETRITDKKCSRHQVQLVADYKnRIVTVTQFGTNPSSVEEITLNRGGSTLLK 80  coelacanth
TFJ96946     281 QCSLVSGDgrhEPVALP-DGVPVVLGRGPRTRVADKKCSRTQVELLADYKhRAVRVTQRGVNPTSVEELQLQPGDSSTLQ 359 big-headed turtle

Feature 1                #           
2W3O_A        92 vGDTLYLVNGEHPLTLRWEE 111 Homo sapiens
1UJX_A        96 lGDVLYLVNGLYPLTLRWSG 115 Mus musculus
1YJ5_C        89 lGDVLYLVNGLYPLTLRWEE 108 Mus musculus
1YJM_A        89 lGDVLYLVNGLYPLTLRWEE 108 Mus musculus
2BRF_A        89 vGDTLYLVNGLHPLTLRWEE 108 Homo sapiens
Q96T60        89 vGDTLYLVNGLHPLTLRWEE 108 human
NP_001071046  79 tGQTLYLVNESYPFTVEFAF 98  zebrafish
NP_001108303  81 eDQILFMVNGLHPYTVLFKE 100 African clawed frog
XP_005990984  81 eGQTLFIVNGLHPQTLLFKE 100 coelacanth
TFJ96946     360 eGQTLWLVNGRYPYTLRFLP 379 big-headed turtle

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