Conserved Protein Domain Family
FHA_RADIL
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cd22733: FHA_RADIL 
forkhead associated (FHA) domain found in Ras-associating and dilute domain-containing protein (Radil)
Radil acts as an important small GTPase Rap1 effector required for cell spreading and migration. It regulates neutrophil adhesion and motility through linking Rap1 to beta2-integrin activation. It contains an FHA domain. The FHA domain is a small phosphopeptide recognition module, but this group may lack the conserved residues that are required for binding phosphothreonine.
Links
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Statistics
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PSSM-Id: 438785
Aligned: 6 rows
Threshold Bit Score: 185.001
Created: 14-Sep-2020
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q96JH8        244 SLYQSPHLLLLQGYSQqHDSLVYVLNRDRHTVGQRTpSSKPSISLSAPDILPLHCTIRRQplpds--gqaaGRLVLEPIP 321  human
A7UA95        256 SLYQSPHLLLLQGYNQ-QDCLVYLLNREQHTVGQETaSARPNICLSSPDVLPLHCRIRRAaqrr---sssdQRLLLEPVA 331  zebrafish
XP_006010299   88 SLYQSPHLLLLQGYSQqSDCLVYLLNREQHIAGRETpSTKPNITLSAPDTLPLHCKIRKVkllnkytrnreEKLVLETAP 167  coelacanth
XP_004945204  267 SLYHSPHLLLLQGYSQqHDSLVYLLNREQHTVGQRTqASKPSISLSAPDILPLHCTIRRLrasw---hrseEKLVLEPIA 343  chicken
XP_007904326  269 SVGQLPHLLLLQGYNHpNDGLVYPLDGESHIVGRETaSAKPNICLLAPDILPLHCRVRRVrgak---ageqRVLELEPFP 345  elephant shark
XP_029433354  278 SLYQCPHLLLLQGYNRqHDNLVYLLNREQYTVGQRTpSSKPSISLSAPDILPLHCTVRKIkppsrsghrseEKLVLEPIP 357  two-lined cae...

Q96JH8        322 GAHISVNFSEVGhRTVVLHHGDLLSLGlYYLLLFKDP 358  human
A7UA95        332 HGNVLVNFMRIE-RPTPIRHGDLLSFGaHYIFLYKDP 367  zebrafish
XP_006010299  168 GAHVSVNFSKVE-RATLLHHGDLLSFGaQYIFLFKDP 203  coelacanth
XP_004945204  344 GASVSVNFSAVT-RTVVLRHGDLLSLGlYYLLLYKDP 379  chicken
XP_007904326  346 DARVSVSLSQVE-QATALRHGDLVGFGrCYLFLFRDP 381  elephant shark
XP_029433354  358 GASISVNFSEVG-KTTLLHHGDLLSLGcYYLFLFKDP 393  two-lined caecilian
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