3FM8


Conserved Protein Domain Family
FHA_KIF13B

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cd22730: FHA_KIF13B 
Click on image for an interactive view with Cn3D
forkhead associated (FHA) domain found in kinesin-like protein KIF13B
KIF13B, also called kinesin-like protein GAKIN, is a novel kinesin-like protein that associates with the human homolog of the Drosophila discs large tumor suppressor in T lymphocytes. It is involved in reorganization of the cortical cytoskeleton. It regulates axon formation by promoting the formation of extra axons. KIF13B may be functionally important for the intracellular trafficking of membrane-associated guanylate kinase homologs (MAGUKs) and associated protein complexes. The FHA domain is a small phosphopeptide recognition module, but this group may lack the conserved residues that are required for binding phosphothreonine.
Statistics
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PSSM-Id: 438782
Aligned: 6 rows
Threshold Bit Score: 209.77
Created: 4-Sep-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
heterodimer
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:3FM8; Homo sapiens KIF13B in complex with ADAP1 through its FHA domain, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              ######     #                                                # # ##         
3FM8_A         26 KCFLVNLNADPALNELLVYYLKEHTLIGSANSQDIQLCGMGILPEHCIIDITsEGQVMLTPQKNTRTFVNGSSVSSPIQL 105  human
XP_700210     450 KCFLVNLNADPALNELLVYYLKEHTKVGSADSQDIQLCGMGIQAEHCVINITpEGAVFINPYRNSRTCVNGSPVTSRQQL 529  zebrafish
NP_001138546  447 KCFLVNLNADPALNELLVYYLKDHTLIGSHDSQDIQLCGLGILPEHCIIDISpEGQVILTPMKNTRTYVNGSAVSKATQL 526  African clawe...
XP_003641120  447 KCFLVNLNADPALNELLVYYLKEHTLIGSDNSQDIQLCGMGILPEHCIIDITpEGQVMLTPQKNTRTFVNGSAVTGPIQL 526  chicken
Q9NQT8        447 KCFLVNLNADPALNELLVYYLKEHTLIGSANSQDIQLCGMGILPEHCIIDITsEGQVMLTPQKNTRTFVNGSSVSSPIQL 526  human
XP_007906744  446 KCFLVNLNADPALNELLVYYLKNHTLVGSDDSQDIQLCGMGILPAHCLIDISaERTVILTPKPNSRTFVNGCMVTSPVQL 525  elephant shark
Feature 1             # #  ## #      
3FM8_A        106 HHGDRILWGNNHFFRLNLP 124  human
XP_700210     530 HHGDRILWGNNHFFRINLP 548  zebrafish
NP_001138546  527 QHGDRILWGNNHFFRISLP 545  African clawed frog
XP_003641120  527 HHGDRILWGNNHFFRLNLP 545  chicken
Q9NQT8        527 HHGDRILWGNNHFFRLNLP 545  human
XP_007906744  526 HHGDRILWGNNHFFRINLP 544  elephant shark

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