2EH0


Conserved Protein Domain Family
FHA_KIF1B
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cd22727: FHA_KIF1B 
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forkhead associated (FHA) domain found in kinesin-like protein KIF1B
KIF1B, also called Klp, is a motor for anterograde transport of mitochondria. It has a microtubule plus end-directed motility. Isoform 1 mediates the transport of synaptic vesicles in neuronal cells, while isoform 2 is required for induction of neuronal apoptosis. The FHA domain is a small phosphopeptide recognition module, but this group may lack the conserved residues that are required for binding phosphothreonine.
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Statistics
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PSSM-Id: 438779
Aligned: 7 rows
Threshold Bit Score: 247.256
Created: 4-Sep-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2EH0_A          7 GTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCErSETYVNG 86   human
O60333        530 KTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCErSETYVNG 609  human
XP_004947518  484 KTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERNNNGEVIVTLEPCErSETYVNG 563  chicken
XP_007900342  530 KTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCSFRSDKIQNGEVIVTLVPCEaSETYVNG 609  elephant shark
XP_014347096  484 KTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERKENGEVIVTLEPCEgSETYVNG 563  coelacanth
NP_919363     483 KTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERNANGHVIVTLEPCEgSETYVNG 562  zebrafish
XP_018081121  527 KTPHLVNLNEDPLMSECLLYYIKDGLTRVGQADADSHQDIVLSGAHIKEEHCIFRSERNSNGEVIVTLEPCEsSETYVNG 606  African clawe...

2EH0_A         87 KRVSQPVQLRSGNRIIMGKNHVFRFNHPEQ 116  human
O60333        610 KRVSQPVQLRSGNRIIMGKNHVFRFNHPEQ 639  human
XP_004947518  564 KRVVQPVQLRSGNRIIMGKNHVFRFNHPEQ 593  chicken
XP_007900342  610 KRVTTPVKLRSGNRIIMGKNHVFRFTHPEQ 639  elephant shark
XP_014347096  564 KRVGESVQLRSGNRIIMGKNHVFRFNHPEQ 593  coelacanth
NP_919363     563 KRVNSAVQLRSGNRIIMGKNHVFRFNHPEQ 592  zebrafish
XP_018081121  607 KRVVLPVVLRSGNRIIMGKNHVFRFNHPEQ 636  African clawed frog
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