Conserved Protein Domain Family
FHA_Cep170B
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cd22725: FHA_Cep170B 
forkhead associated (FHA) domain found in centrosomal protein of 170 kDa protein B (Cep170B) and similar proteins
Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.
Links
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Statistics
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PSSM-Id: 438777
Aligned: 6 rows
Threshold Bit Score: 227.502
Created: 4-Sep-2020
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative
Feature 1:putative phosphopeptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on structures of other FHA domains with bound phosphopeptide
  • Comment:GR at the C terminus of strand beta3, SRxH just preceding beta5, and motif SxNG in the beta6-beta7 turn indicate a canonical mode of pThr recognition.
  • Comment:Conserved residues are involved in binding directly to the ligand backbone and phosphate group. Non-conserved residues may determine binding specificity.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                  ##            ## #                  # ##               
Q9Y4F5          1 MSATSWFLVSSSGARHRLPRELIFVGREECELMLQSRSVDKQHAVINYDQDrDEHWVKDLGSLNGTFVNDMRIPDQKYVT 80   human
XP_015143345    1 MSVTSWFLVSSTGIRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDKEkDEHWVKDLGSLNGTFVNDVRIPDQKYIT 80   chicken
XP_005160385    1 MSVTSWFLVSSSGTRHRLPREMIFVGREDCELMLQSRSVDKQHAVINYNPAtDEHLVKDLGSLNGTFVNDLRIPDQTYIT 80   zebrafish
XP_007886426    1 MSVTSWFLVSTCGSRHRLPKEMIFVGREDCELMLQSRSVDKQHAVINYDLTtDEHRVKDLGSLNGTFVNDIRIPDQMYIT 80   elephant shark
Q498L0          1 MSVTSWFLVSSSGTRHRLPREMIFVGREDCELMLRSRSVDKQHAVINYDSDkDEHRVKDLGSLNGTFINDVRIPDQKYIT 80   African clawe...
XP_017708295    1 MSATSWFLVSSSGARHRLPRELIFVGREECELMLQSRSVDKQHAVINYDQDrDEHWVKDLGSLNGTFVNDMRIPDQKYVT 80   black snub-no...

Feature 1                                   
Q9Y4F5         81 LKLNDVIRFGYDSNMYVLERVQHRVP 106  human
XP_015143345   81 LKLNDVIRFGYDSNMYVLEQIQHKVP 106  chicken
XP_005160385   81 LKLSDIVRFGYDSHVYILERSQHKVP 106  zebrafish
XP_007886426   81 LKVKDTIRFGYDSNQYTLEKSTHTVP 106  elephant shark
Q498L0         81 LKLNDNIRFGYDINTYVLEQIQHQVP 106  African clawed frog
XP_017708295   81 LKLNDVIRFGYDSNMYVLERVQHRVP 106  black snub-nosed monkey

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