6I2P,2XT9,2KFU,2KKL


Conserved Protein Domain Family
FHA_GarA-like
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cd22720: FHA_GarA-like 
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forkhead associated (FHA) domain found in Mycobacterium tuberculosis glycogen accumulation regulator GarA and similar proteins
GarA is an FHA domain-containing protein involved in the regulation of glutamate metabolism. It acts as a phosphorylation-dependent ON/OFF molecular switch that modulates the activities of KGD, GDH and GltB. Its FHA domain has dual specificity. It binds to both phosphorylated upstream partners, such as the kinases PknB and PknG, and nonphosphorylated downstream partners, such as the 2-oxoglutarate decarboxylase KGD. The FHA domain is a small phosphopeptide recognition module.
Links
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Statistics
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PSSM-Id: 438772
Aligned: 6 rows
Threshold Bit Score: 190.216
Created: 15-Sep-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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partner proteinputative
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:partner protein binding site [polypeptide binding site]
Evidence:
  • Comment:The GarA FHA domain binds to both phosphorylated upstream and nonphosphorylated downstream partners.
  • Structure:2XT9; Mycobacterium Smegmatis GarA in complex with 2-oxoglutarate decarboxylase, contacts at 4A
  • Structure:6I2P; Mycobacterium tuberculosis GarA in complex with PknB through its FHA domain, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  ##                 #      # # ## ##                 # ##  #  #        
6I2P_D        53 PPGSALLVVKRGPNAGSRFLLDQAITSAGRHPDSDIFLDDVTVSRRHAEFRLENNEFNVVDVGSLNGTYVNREPVDSAVL 132 Mycobacterium t...
2XT9_B         8 PSGSALLVVKRGPNAGSRFLLDQPTTSAGRHPDSDIFLDDVTVSRRHAEFRLEGGEFQVVDVGSLNGTYVNREPVDSAVL 87  Mycolicibacteri...
2KFU_A        52 PPGSALLVVKRGPNAGSRFLLDQAITSAGRHPDSDIFLDDVTVSRRHAEFRLENNEFNVVDVGSLNGTYVNREPVDSAVL 131 Mycobacterium t...
2KKL_A        29 PPGLALLVVKRGPNAGSRFLLDQAITSAGRHPDSDIFLDDVTVSRRHAEFRLENNEFNVVDVGSLNGTYVNREPVDSAVL 108 Mycobacterium t...
P9WJA9        52 PPGSALLVVKRGPNAGSRFLLDQAITSAGRHPDSDIFLDDVTVSRRHAEFRLENNEFNVVDVGSLNGTYVNREPVDSAVL 131 Mycobacterium t...
WP_124246635  46 APGTALLVVKRGPNAGSRFLLDQATTSAGRHPDSDIFLDDVTVSRRHAEFRTGDGDFQVVDVGSLNGTYVNREPVDVATL 125 Kroppenstedtia ...

Feature 1              # ## #        
6I2P_D       133 ANGDEVQIGKFRLVFLTGPK 152 Mycobacterium tuberculosis H37Rv
2XT9_B        88 ANGDEVQIGKFRLVFLTGPK 107 Mycolicibacterium smegmatis MC2 155
2KFU_A       132 ANGDEVQIGKFRLVFLTGPK 151 Mycobacterium tuberculosis
2KKL_A       109 ANGDEVQIGKFRLVFLTGHK 128 Mycobacterium tuberculosis variant bovis
P9WJA9       132 ANGDEVQIGKFRLVFLTGPK 151 Mycobacterium tuberculosis H37Rv
WP_124246635 126 GNGDEVQIGKFRLVFLSGPR 145 Kroppenstedtia sanguinis

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