Conserved Protein Domain Family
FHA_PHLB1
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cd22713: FHA_PHLB1 
forkhead associated (FHA) domain found in pleckstrin homology-like domain family B member 1 (PHLDB1) and similar proteins
PHLDB1, also called protein LL5-alpha (LL5A), acts as an insulin-responsive protein that enhances Akt activation. PHLDB1 contains a pleckstrin homology domain, which binds phosphatidylinositol PI(3,4)P(2), PI(3,5)P(2), and PI(3,4,5)P(3), as well as a Forkhead-associated (FHA) domain and coiled coil regions. The FHA domain is a small phosphopeptide recognition module, but this group may lack the conserved residues that are required for binding phosphothreonine.
Links
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Statistics
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PSSM-Id: 438765
Aligned: 14 rows
Threshold Bit Score: 199.089
Created: 7-Sep-2020
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q86UU1         24 LDLIETGKGLKVQTDkPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARdi------sLQGPGLAPEHCYIENLrGTLTLY 97   human
XP_007906908   30 LDIIDIGKGLKMQSErPHLVSLGRGRLSIAITLLPINEGETKFGLEDApepq--diiLQGPDVATEHCYIENIkGLVTLY 107  elephant shark
XP_013411898   13 IEVTEIGKSYKVQTDkPHLVSLGSGRLSTAVTLLPLPEGVTSIGTAENnd-----ivIQGTGCEADHCTVENCnGLVTLY 87   Lingula anatina
XP_014350590   30 LDLIDTGKGLKVQAEkPHLVSLGSGRLSTAITLLPLEEGKTTIGSTTNdi------sIQGPGIAPEHCYIDNRnGIITLY 103  coelacanth
XP_029636132   22 LEVTEAGSAYKVHSEkPHLVSLGSGRLSTAVTLLSLNEGITKIGTSDAttlq--divIQGTGVESEHCFIENKnNIITLY 99   Octopus vulgaris
XP_011678771   77 LELSETGRALKVQSErPHLVSLGGSRISTAVTLLPLPEGKTNIGTNEAsvrq--dvlITGRDVLPQHCCVENLnDTVVLY 154  Strongylocent...
XP_005157509   58 LDLIETGKALKVQAErPHLVSLGSGRLSTAITLLPLPEGKTTVGHGAMdi------sIQGPGVAAQHCFIENRaGIITLH 131  zebrafish
EFX84806      414 CEQGHNALKVRTADCgPHLVSLGSGRLSTNITLIHLPEGRILMGCGGSyvqrqpdvhVQGTGVEPIHCYIENInGTVSLY 493  Daphnia pulex
RMX42126      459 LAVTELGSALKFETDePHFVSLGGGRLSIGVTLCPIKRGKTVIGVATEtckp--diqLRGKGIEPEHCTVEYNgDAVVLY 536  Pocillopora d...
EEC05316       61 LEVIETSRTVRVHQEkPHLVSLGGGRLSTSVTIHPLPEGKTRIGRSDAptlq--divVQGPGVEAEHCYIQNEsGKVTLY 138  black-legged ...

Q86UU1         98 PCgNACTIDGLPVRqPTRLTQGCMLCLGQSTFLRFNHPAEAKWMK 142  human
XP_007906908  108 PCgSLCTMDGFFITqPTKLTQGCTLCLGQSNYFRFNHPAEANRMR 152  elephant shark
XP_013411898   88 PGaDLCSVDGLKVNrPTILSQGCMLCLGRSNYFRFNHPQEAIRMK 132  Lingula anatina
XP_014350590  104 PCgNICALDGLKVSqPIRLTQGCMICLGQATFFRFNHPAEALRMK 148  coelacanth
XP_029636132  100 PIaKMCALDGVIITkPTRLAQGSMLCLGRSNYFRFNHPQEAKMIK 144  Octopus vulgaris
XP_011678771  155 PI-GACSVDGDRITsPTKLTQGAMLCFGKSCFFRFNNPSEAKQLK 198  Strongylocentrotus purpuratus
XP_005157509  132 PCgNQCSMDGLPVNkPVRLSQGCMLCFGQSAFFRFNHPEEAFRMK 176  zebrafish
EFX84806      494 PLgEMTSVDGLPVAtPIRLTQGSMICVGRSNYFRFNHPEEAERMK 538  Daphnia pulex
RMX42126      537 PKaNLCSVDGIPISePTRLPQGCMICLGKSNYFRFNHPREAKRIK 581  Pocillopora damicornis
EEC05316      139 PVaKVISIDGMTVTePSRLHQGCMICIGRSNFFRFNHPEEAQNLK 183  black-legged tick
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