Conserved Protein Domain Family
FHA_FHAD1
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cd22700: FHA_FHAD1 
forkhead associated (FHA) domain found in forkhead-associated domain-containing protein 1 (FHAD1) and similar proteins
FHAD1, also called FHA domain-containing protein 1, is an uncharacterized FHA domain-containing protein. The FHA domain is a small phosphopeptide recognition module.
Links
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Statistics
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PSSM-Id: 438752
Aligned: 13 rows
Threshold Bit Score: 165.505
Created: 4-Sep-2020
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative
Feature 1:putative phosphopeptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on structures of other FHA domains with bound phosphopeptide
  • Comment:GR at the C terminus of strand beta3, SRxH just preceding beta5, and motif SxNG in the beta6-beta7 turn indicate a canonical mode of pThr recognition.
  • Comment:Conserved residues are involved in binding directly to the ligand backbone and phosphate group. Non-conserved residues may determine binding specificity.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                ##                         ## #                  # ##    
B1AJZ9          2 KAYLKSAE--GFFVLN--KSTTIGRHEn-----------SDLVLqs-pDIDNHHALIEYNeaECSFVLQDFNSRNGTFVN 65   human
XP_013409826    2 KGYLKGTE--GVFLLAp-KVTTVGREG------------CDLAIqs-lNVDQQHAVIEYSdqEQCYVLQDLNTATGTYVN 65   Lingula anatina
ELT87041        2 KGYLKNQE--GIFQLAp-KVTTVGKEG------------CDLVIpt-hGVDYQHAVIEFSqqEDCFVLQDLNTAQGTYVN 65   Capitella teleta
XP_006812789    2 KGYLRGGE--VIFPLNvpNVTTVGREG------------CDLTIes-cNVELTHAVIELNevENCFVLQDLNTAQGTYVN 66   Saccoglossus ...
XP_013074726    5 KAFLKGADg-SLFPLLh-KVTTVGREN------------CDLTIql-pGVDYQHCVLEYNeiDDCFIIQDLNTAQGTYVN 69   Biomphalaria ...
NP_001035472    2 RGLLKTPN--WVFKLQp-KTTTIGRHKd-----------SDLCLqn-sGVDEYHATIDWCeaDSCYVIRDLNSAHGTYVN 66   zebrafish
XP_004225891    2 RGYLRSPG--HMYYLDt-DVTSVGRGSglkppdqlknvgAHIPLgs-gKVEHFHAVVEKRaqENCFILVDMNTAYGTYVN 77   vase tunicate
XP_024998510    2 RAFLRSSE--ECFQLKq-QRTTIGRHEg-----------SDIVLks-aGAEEHHAALEFTgwESGFVLQDLNSPQGTFVN 66   chicken
XP_030042056    2 KGFLKFSD--SIFVLKp-KVTTIGRHGd-----------SDLVLks-aDIEEHHAHIELNelENCFVLHDLNSLHGTFVN 66   Microcaecilia...
RMX43685        2 KACLRSRDgsCIHQLRq-PLTTIGCEG------------SDVIIqqcsNVERQHAVIEYDetEGCFVVQDLNSAHGTYVN 68   Pocillopora d...
RDD42410        2 KGYLKSSD--GLFLLDp-RFTTIGRDN------------CDLLLqs-pNLERRHAIIEYHdsDGHYYLRDLNTANGTYVN 65   Trichoplax sp...
PAA47023        7 RGVLKCRD--EEYQLCp-KITTIGSTG------------CDIIVea-eGTESQHAIIEYSeeDGGFILKDLNTEYGTRIN 70   Macrostomum l...
XP_002610857    2 KGFLKSQD--GVVALGp-KVTTVGREN------------CDLSIqa-qSVERQHAVVEYSdvENCFVLQDLNTVQGTYVN 65   Florida lancelet

Feature 1                                           
B1AJZ9         66 ECHIQNVAVKLIPGDILRFGs--aGLTYELVIEN 97   human
XP_013409826   66 DCRVQNAAVRLAPGDVVRFGf--nGTPYELQIDN 97   Lingula anatina
ELT87041       66 DCRVQNAAVRLAPGDIIRFGf--gGLPYELDVEN 97   Capitella teleta
XP_006812789   67 DCRVQNAAVRLAPGDVIRFGf--sGLPYELEIEN 98   Saccoglossus kowalevskii
XP_013074726   70 DVRIQNAAVRLAPGDHVRFSy--nGQPFELQLDS 101  Biomphalaria glabrata
NP_001035472   67 DCRIHNATVRLSPGDQLHFGy--gGSTYELSIDN 98   zebrafish
XP_004225891   78 EHRIQNGAVRLAPGDVVRFGhggiPHEFNLVMED 111  vase tunicate
XP_024998510   67 GCQVQNAAVHVGPGDVLRFGa--rGASFELMVDG 98   chicken
XP_030042056   67 DCHIQNAAVKLSPGDVLRFGs--sGFCYELLLEN 98   Microcaecilia unicolor
RMX43685       69 ECRVQNAAVRLASGDIIRFGy--eNTGFEFLVDS 100  Pocillopora damicornis
RDD42410       66 DKVIQNGYIQLAPGDILRFDf--dGIAFQFDTDE 97   Trichoplax sp. H2
PAA47023       71 DCLVQNAAVRLSPGDQLRFGq--gQAVYQLAVQQ 102  Macrostomum lignano
XP_002610857   66 DCRIQNAAVRLAPGDMIQFGf--gGMPYELVVED 97   Florida lancelet

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