3HX1


Conserved Protein Domain Family
FHA_Slr1951-like
?
cd22697: FHA_Slr1951-like 
Click on image for an interactive view with Cn3D
forkhead associated (FHA) domain found in Synechocystis sp. Slr1951 protein and similar proteins
This subfamily corresponds to a group of uncharacterized FHA domain-containing proteins which show high sequence similarity with Synechocystis sp. protein Slr1951 and protein Sll1895. The FHA domain is a small phosphopeptide recognition module.
Links
?
Statistics
?
PSSM-Id: 438749
Aligned: 6 rows
Threshold Bit Score: 137.211
Created: 16-Sep-2020
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
Conserved Features/SitesClick to see Conserved Features Help
 
putative
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:putative phosphopeptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on structures of other FHA domains with bound phosphopeptide
  • Comment:GR at the C terminus of strand beta3, SRxH just preceding beta5, and motif SxNG in the beta6-beta7 turn indicate a canonical mode of pThr recognition.
  • Comment:Conserved residues are involved in binding directly to the ligand backbone and phosphate group. Non-conserved residues may determine binding specificity.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 ##             ## #                           # ##     
3HX1_A        13 ILIILDDa-GRREVLLTe--tFYTIGRSprADIRIKSqFVSRIHAVLVRKssd-dvqAAYRIIDGdedgQSSVNGLXING 88  Synechocystis s...
BAM50468       5 ILVLEDAn-QRRTIILDe--qQYSIGRHsgTSIQIHSrQASRHHATLMRKtnsktneECFWIIDGdlegNKSQNGVFVNG 81  Bacillus subtil...
P74101         3 YQLVVDSpsFKKVIRLQn--sCYSIGRHpsNTIVIPSpQISRRHATLIKKinp-nldISFHIIDGdlegHRSRNGVWVNG 79  Synechocystis s...
WP_129893243 724 VIVEIDGn-TIGEYQLSk--lIFTIGRFptSDIQIDSqRVSRFHAIIRWK-------YGSWVIED----AESLNGLSFQG 789 Ktedonobacteral...
TMD61131     359 VLIELDGk-VVGERRLDk--pLITIGRQqgSDVCVPNqRISRLHARIRYE-------NNTWVIDD----AESLNGIIYQG 424 Chloroflexi bac...
TMC20958     684 ILVELDGk-VVDEYRLDprkpIVTIGRVemNDVAIPSrAISRMHARVRRN-------GDVWLIED----AESLNGLMYGG 751 Chloroflexi bac...

Feature 1                                  
3HX1_A        89 KKVqeHIIQTGDEIVXGPQVSVRYEY 114 Synechocystis sp. PCC 6803
BAM50468      82 EKRliHELKNGDLINFGCSINASYHV 107 Bacillus subtilis BEST7613
P74101        80 ESHldYELVHGDVIALSEDIQIFYQA 105 Synechocystis sp. PCC 6803 substr. Kazusa
WP_129893243 790 QRIeqLALEDKDEVHLDPTIILRYEE 815 Ktedonobacterales bacterium SCAWS-G2
TMD61131     425 TRIerLALTNGDQIYLAPKAVLHYQT 450 Chloroflexi bacterium
TMC20958     752 ERIdqMPLSNGDRVMLAPKAVLQYVA 777 Chloroflexi bacterium

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap