1G6G,5XZV,6C4U,1J4O,2A0T,5T2F,5T2S,6C4U,2JQI,1J4P


Conserved Protein Domain Family
FHA_RAD53-like_rpt1
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cd22689: FHA_RAD53-like_rpt1 
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first forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine/threonine-protein kinase RAD53 and similar proteins
RAD53, also called CHEK2 homolog, or serine-protein kinase 1 (Spk1), is a nuclear protein kinase that phosphorylates proteins on serine, threonine, and tyrosine. It controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints and prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. It may be involved in the phosphorylation of RPH1. RAD53 contains two FHA domains. This model corresponds to the first one. The FHA domain is a small phosphopeptide recognition module.
Links
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Statistics
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PSSM-Id: 438741
Aligned: 13 rows
Threshold Bit Score: 171.304
Created: 4-Sep-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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phosphopeptide
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:phosphopeptide binding site [polypeptide binding site]
Evidence:
  • Structure:1G6G; Saccharomyces cerevisiae Rad53p FHA domain binds a phosphothreonine peptide, contacts at 4A
  • Structure:6C4U; Saccharomyces cerevisiae Rad53p FHA in complex with Myc-pTBD peptide, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                               ###   
1G6G_A      7 RVICTTGQi------------------------PIRDLSAdisqvlk---------------ekrsikKVWTFGRNPaCD 47  baker's yeast
5XZV_A     35 RVICTTGQi------------------------PIRDLSAdisqvlk---------------ekrsikKVWTFGRNPaCD 75  Saccharomyces cere...
6C4U_A      7 RVISTTGQi------------------------PIRDFSAdisqvlk---------------ekrsikKVWTFGRNPaCD 47  baker's yeast
1J4O_A     22 RVICTTGQi------------------------PIRDLSAdisqvlk---------------ekrsikKVWTFGRNPaCD 62  baker's yeast
2A0T_A     22 RVICTTGQi------------------------PIRDLSAdisqvlk---------------ekrsikKVWTFGRNPaCD 62  baker's yeast
5T2F_A    142 RVICTTGQi------------------------PIRDLSAdisqvlk---------------ekrsikKVWTFGRNPaCD 182 Saccharomyces cere...
5T2S_A    137 RVICTTGQi------------------------PIRDLSAdisqvlk---------------ekrsikKVWTFGRNPaCD 177 Saccharomyces cere...
6C4U_B      7 RVISTTGQi------------------------PIRDFSAdisqvlk---------------ekrsikKVWTFGRNPaCD 47  baker's yeast
2JQI_A     22 RVICTTGQi------------------------PIRDLSAdisqvlk---------------ekrsikKVWTFGRNPaCD 62  unidentified
1J4P_A     22 RVICTTGQi------------------------PIRDLSAdisqvlk---------------ekrsikKVWTFGRNPaCD 62  baker's yeast
P22216     35 RVICTTGQi------------------------PIRDLSAdisqvlk---------------ekrsikKVWTFGRNPaCD 75  Saccharomyces cere...
Q09170      5 EEATQATQeaplhvsqniakqvvnnenvfmklvMTRMLDGktevipl---------------ttdvhnGFWRFGRHKsCE 69  Schizosaccharomyce...
CDZ96170   15 FQATQTGPqtqtqsqs---------qsltmtqeGIVDYWGslllmsraassqtstgfqqgllrlyntkRVYKVGRHHgCD 85  

Feature 1         # #####                           ##                                        
1G6G_A     48 YHLGNiSRLSNKHFQILLGe-------dGNLLLNDI-STNGTWLNGQKVEknsNQLLSQGDEITVGvgvesDILSLVIFI 119 baker's yeast
5XZV_A     76 YHLGNiSRLSNKHFQILLGe-------dGNLLLNDI-STNGTWLNGQKVEknsNQLLSQGDEITVGvgvesDILSLVIFI 147 Saccharomyces cere...
6C4U_A     48 YHLGNiLPVSNKHFQILLGe-------dGNLLLNDI-STNGTWLNGQKVEknsYQLLSQGDEITVRtdptgTILSLVIFI 119 baker's yeast
1J4O_A     63 YHLGNiSRLSNKHFQILLGe-------dGNLLLNDI-STNGTWLNGQKVEknsNQLLSQGDEITVGvgvesDILSLVIFI 134 baker's yeast
2A0T_A     63 YHLGNiSRLSNKHFQILLGe-------dGNLLLNDI-STNGTWLNGQKVEknsNQLLSQGDEITVGvgvesDILSLVIFI 134 baker's yeast
5T2F_A    183 YHLGNiSRLSNKHFQILLGe-------dGNLLLNDI-STNGTWLNGQKVEknsNQLLSQGDEITVGvgvesDILSLVIFI 254 Saccharomyces cere...
5T2S_A    178 YHLGNiSRLSNKHFQILLGe-------dGNLLLNDI-STNGTWLNGQKVEknsNQLLSQGDEITVGvgvesDILSLVIFI 249 Saccharomyces cere...
6C4U_B     48 YHLGNiLPVSNKHFQILLGe-------dGNLLLNDI-STNGTWLNGQKVEknsYQLLSQGDEITVRtdptgTILSLVIFI 119 baker's yeast
2JQI_A     63 YHLGNiSRLSNKHFQILLGe-------dGNLLLNDI-STNGTWLNGQKVEknsNQLLSQGDEITVGvgvesDILSLVIFI 134 unidentified
1J4P_A     63 YHLGNiSRLSNKHFQILLGe-------dGNLLLNDI-STNGTWLNGQKVEknsNQLLSQGDEITVGvgvesDILSLVIFI 134 baker's yeast
P22216     76 YHLGNiSRLSNKHFQILLGe-------dGNLLLNDI-STNGTWLNGQKVEknsNQLLSQGDEITVGvgvesDILSLVIFI 147 Saccharomyces cere...
Q09170     70 VVLNG-PRVSNFHFEIYQGhrndsdeseNVVFLHDH-SSNGTFLNFERLAknsRTILSNGDEIRIGlgvpkDEISFLCQV 147 Schizosaccharomyce...
CDZ96170   86 IQFDE-SRISNSHLTFTLNdsd---psgIIVIIEDLrSSNGTYVNNQRLPpkqKRVLKHGDEIFIGqr-tgHTAGGGVKL 160 

Feature 1      
1G6G_A    120 N 120 baker's yeast
5XZV_A    148 N 148 Saccharomyces cerevisiae S288C
6C4U_A    120 N 120 baker's yeast
1J4O_A    135 N 135 baker's yeast
2A0T_A    135 N 135 baker's yeast
5T2F_A    255 N 255 Saccharomyces cerevisiae S288C
5T2S_A    250 N 250 Saccharomyces cerevisiae S288C
6C4U_B    120 N 120 baker's yeast
2JQI_A    135 N 135 unidentified
1J4P_A    135 N 135 baker's yeast
P22216    148 N 148 Saccharomyces cerevisiae S288C
Q09170    148 P 148 Schizosaccharomyces pombe 972h-
CDZ96170  161 L 161

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