4H87


Conserved Protein Domain Family
FHA_Kanadaptin
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cd22677: FHA_Kanadaptin 
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forkhead associated (FHA) domain found in kanadaptin and similar proteins
Kanadaptin, also called human lung cancer oncogene 3 protein (HLC-3), kidney anion exchanger adapter protein, or solute carrier family 4 anion exchanger member 1 adapter protein (SLC4A1AP), is a nuclear protein widely expressed in mammalian tissues. It was originally isolated as a kidney Cl-/HCO3- anion exchanger 1 (kAE1)-binding protein. It is a highly mobile nucleocytoplasmic shuttling and multilocalizing protein. Its role in mammalian cells remains unclear. It contains an FHA domain, which is a small phosphopeptide recognition module.
Links
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Statistics
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PSSM-Id: 438729
Aligned: 36 rows
Threshold Bit Score: 152.325
Created: 4-Sep-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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homodimerputative
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:4H87; Homo sapiens kanadaptin FHA domain forms a homodimer, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            # # ## ##                                                                   
4H87_A        20 PYSLETLKGGTILGTRSLKg------tSYCLFGRLs-gCDVCLeHPSVSRYHAVLQHRasgpdg---------------- 76  human
XP_024395292 187 PFMLEVLKEGVILGNLDVSs------kGAYMFGRSd-rCDFILeHPSASRYHAVLQYNd--------------------- 238 Physcomitrella ...
NP_198700    102 QFQLEVLKEGAIVEKLDVYk------kGAYLFGRDg-iCDFALeHPSISRFHAVIQYKr--------------------- 153 thale cress
KYQ91361      84 KYKIEVIKGGVVVEDIDIGs------rAYYLIGRIp-iCDIVLdHISISRQHAVIQHRrd-------------------- 136 Tieghemostelium...
XP_004367766  72 AYALEVVKGGVQVERFDVSa------kDHFVVGRAe-gCDLVLlHPSISRRHAVIQHRagrtitnndnahnddddvsndd 144 Acanthamoeba ca...
XP_022838188  67 EFYLDCLKGGTMLERAALGaradgtrgSWVSFGRHp-sCDVVVeHPSTSRLHCVIQFKkd-------------------- 125 Ostreococcus tauri
XP_024526862  55 PYFLEVLKDGSILEELPVSe------kGAYMFGRHe-nCDFALdHPSISRHHAVLQYNs--------------------- 106 Selaginella moe...
XP_013238770  22 TAIFEVIREGVQMEPLILNfda--hqkSYFLAGRSp-lCDLRLeHPSASRFHAVFQMRss-------------------- 78  Mitosporidium d...
CCA16643      18 NISLEAIKAGSVIDEISFPky-----kSYQIAGRMkegCDVHFnHPSISRTHAVFQFDe--------------------- 71  Albugo laibachi...
CDW88843      16 DYYFEVMKEGAILEEIHLNe------kPFYLVGRSkevCDVFMeNPTISRKHAIIQHKd--------------------- 68  Stylonychia lemnae

Feature 1                               ##           #####        # ####
4H87_A        77 -ecdsngPGFYLYDLgSTHGTFLNKTRIPPRTYCRVHVGHVVRFGgSTRLFILQG 130 human
XP_024395292 239 ------kGEAFVYDLgSTHGTFVNKRQVKPRVYTPVHVGAIFRFGlSIRLYVLQG 287 Physcomitrella patens
NP_198700    154 ------sGAAYIFDLgSTHGTTVNKNKVDKKVFVDLNVGDVIRFGgSTRLYIFQG 202 thale cress
KYQ91361     137 ------sKMLFIYDLgSSHGTFINKQRIKANSYQPIKNGDILKFGeSTRILVLTC 185 Tieghemostelium lacteum
XP_004367766 145 dddavdgGGVFVYDLgSTHGTFVGKRRVGARQYCELRVGDMVRFGaSTRMFVLTA 199 Acanthamoeba castellanii str. Neff
XP_022838188 126 ------tTEVYVYDCgSAHGTFVNKRRVKPNVHAPVRVGDHIKLGeSSRVYILDG 174 Ostreococcus tauri
XP_024526862 107 ------nGDAFIFDLsSTHGTFVNKLKVKAKVHVPVHVGSIFRFGlSTRMYLFQG 155 Selaginella moellendorffii
XP_013238770  79 ------dGSIMVVDLnSVNGTFLNKQPLKKDEPIKLHIGDMIQFGkSSRLYICSK 127 Mitosporidium daphniae
CCA16643      72 ------qGKLFLMDLkSTHGTFLNKKRIHPGKFYALNVGDLLRFGdSTRLYAICG 120 Albugo laibachii Nc14
CDW88843      69 ------tGDIFLYDLgSTHGTFLNKRQIPPNQYIKLKLNDLIRFGqSTRMLILNG 117 Stylonychia lemnae

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