2N84


Conserved Protein Domain Family
FHA_Par42-like
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cd22675: FHA_Par42-like 
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forkhead associated (FHA) domain found in Trypanosoma brucei Parvulin 42 (TbPar42) and similar proteins
TbPar42 is a nuclear protein that plays a key role in parasite cell proliferation. It exhibits an N-terminal forkhead associated (FHA)-domain and a peptidyl-prolyl-cis/trans-isomerase (PPIase) domain, both connected by a linker. Its PPIase domain adopts a parvulin fold and reflects structural elements of Pin1-type proteins but is catalytically inactive. Its FHA domain may be involved in the binding of phosphorylated target proteins. The FHA domain is a small phosphopeptide recognition module.
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Statistics
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PSSM-Id: 438727
Aligned: 3 rows
Threshold Bit Score: 213.957
Created: 21-Sep-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:putative phosphopeptide binding site [polypeptide binding site]
Evidence:
  • Comment:key residues of TbPar42 FHA for binding to phosphopeptide ligands
  • Comment:R97 as well as S112 are expected to form a hydrogen bond network with the phosphate group of the ligand's pThr moiety. The conserved G96 and H114 are most likely crucial for the structural stability of the binding site.
  • Comment:also based on structures of other FHA domains with bound phosphopeptide
  • Comment:GR at the C terminus of strand beta3, SRxH just preceding beta5, and motif SxNG in the beta6-beta7 turn indicate a canonical mode of pThr recognition.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                      ###       ##  #####                  ####      
2N84_A     65 WAALPSVACHLQCTRDGLPLPALGLHRFPFYLFGRSkVCDYVLEHpSISSVHAVLVFHGgqRCFVLMDLGSTNGVKLNGN 144 Trypanosoma brucei...
CUG86328   80 WVAIPAVALHLECLREGVRMAPLSLDRYPTYLLGQSpVCDFRLEHtSISRVHAALAYHGekKCFVVVDLQSTNGVKVNGK 159 Bodo saltans
ACJ71247   65 WAGLPAVACHLQCSRDGVPLPSFGLERFPFYLFGRSrVCDYVLEHpSISSIHAVLVFHGdqQCFVLMDLGSTNGTKLNGS 144 Trypanosoma cruzi

Feature 1      #                  #            
2N84_A    145 RIEkrRPLPAPVGSSIQFGFSSRVYKVQLGPPS 177 Trypanosoma brucei brucei TREU927
CUG86328  160 RVEagRPIPLPVDAVLEFGLSARKYVVRKGAAS 192 Bodo saltans
ACJ71247  145 RIEkkRPLPVPIGSCIQFGFSTRMYKISRGPPP 177 Trypanosoma cruzi

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