5YYZ,5YYX


Conserved Protein Domain Family
FHA_MEK1-like
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cd22670: FHA_MEK1-like 
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forkhead associated (FHA) domain found in Saccharomyces cerevisiae meiosis-specific serine/threonine-protein kinase MEK1 and similar proteins
MEK1 (EC 2.7.11.1), also known as MRE4, is a meiosis-specific protein kinase required for chromosome synapsis and meiotic recombination. The recruitment and activation of MEK1 require the phosphorylation of the chromosome axis protein Hop1 at Thr318 (pT318), which is necessary for recognition by the MEK1 FHA domain. The FHA domain is a small phosphopeptide recognition module.
Links
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Statistics
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PSSM-Id: 438722
Aligned: 26 rows
Threshold Bit Score: 87.6696
Created: 8-Sep-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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phosphopeptide
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:phosphopeptide binding site [polypeptide binding site]
Evidence:
  • Structure:5YYZ; Saccharomyces cerevisiae MEK1 in complex with the HOP1 pThr318 peptide, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                       #                 #        ####                  
5YYZ_A        25 PAHLEVNVggy---nteQTIPIVKHqLVKVGRNDk------ECQLVLTNP--------SISSVHCVFWCVffdedsiPMF 87  Saccharomyces c...
XP_317116     48 RLALETRFscqfqeqfhFVADLCSE-KFNVGRDR-------RCSLAIDEVhfplpirsFISNIHFTLEKDltd--ryTPT 117 Anopheles gambi...
CCE81224      80 HSKLTTSVq-------nLIYPLYSGqVASVGRCPd------LNNISVNHP--------ATSSVHFMIWSVmfdpsstPIL 138 Millerozyma far...
KKY36408      17 QIKVEVKHpgee--tqkDTLYLYANdNLRVGRDEl------HNEIVIDDP--------FVSRLQLEFYTVifdeehyPMV 80  Diaporthe ampelina
CQB88522      26 QEKYARPSisg----nvIVVPLLRQqVLTIGRSP-------KCKVQLINP--------TVSMEHCIIWAIqfdsdsnLIT 86  Chlamydia trach...
OBA21770      13 LGFLKVALndn----ktHVYPIIKNqILSCGREE-------SCDISIQNTn-------YISKIHFRVWCTqfdvsfdPIC 74  Hanseniaspora v...
ORY87841      35 YATLHMRSpfa----qdVVLSVEQEkLYRIGRGP-------SSNLVLTDA--------RVSCTHFTLHSIrvsdsidNLC 95  Protomyces lact...
OUT24607       5 AGWLFDNK---------VRIPLYKNrVIALGRLPleqnnrrIERIQINNS--------RVSATHCYIWHIqfdsntnSIC 67  Pichia kudriavz...
WP_094783071  77 CFMVEIQSeg-----erEPVFLPLGsRITLGRSE-------ENHIRINDP--------YISLTHASFSSIh------DKV 130 Paraburkholderi...
RCK67566      28 HGTVKHSPvd-----nsILVPLQPQqVLTIGRSR-------TSNVHINNP--------TVSMRHAVIWSVqfdeestPVI 87  Candida viswana...

Feature 1              # #                                                                 
5YYZ_A        88 YVKDCSL-NGTYLN-----------GLLLKRd----------kTYLLKHCDVIELSqgseendikKTRLVFMIN 139 Saccharomyces cerevis...
XP_317116    118 YIIDNST-NGTYVN-----------GKLVGRn----------nRAILLPGSTISIAc-------fANIFVYNQH 162 Anopheles gambiae str...
CCE81224     139 YLRDNSL-NGVFVN-----------DHRLGRy----------nSVVLSEGDIIEIKc--------ALKFCVRLY 182 Millerozyma farinosa ...
KKY36408      81 YVRDRDStSGTYVN-----------DKLIGGrenydekkkvcpGRILRHGDVVSVGq--------DVKFEIVHP 135 Diaporthe ampelina
CQB88522      87 YIFDKSR-NGIKHNe---------aDMLFGL------------TGILENRDTIEIKt--------AAHITYKCL 130 Chlamydia trachomatis
OBA21770      75 YIQDLSL-NGTYIV-----------NSKIDEmqki----nknqIKILEKGNTILFPhqlk-mekkDVTIKYVAY 131 Hanseniaspora valbyen...
ORY87841      96 FLTDTSS-NGTYVRyairshgspnsTRLVGKd----------cCVLLSDGDDIEIRh--------VATFTFKQH 150 Protomyces lactucaede...
OUT24607      68 YIKDVSR-NGTLIG-----------GKKMGKg----------nFSILRNNDVISLCg--------GVHFQYLAN 111 Pichia kudriavzevii
WP_094783071 131 YVERLDPsDPLEVN-----------GKIVDL------------KRILATGDVITVPk-------aSMEIKFVRV 174 Paraburkholderia ribe...
RCK67566      88 YVHDLSR-NGILHN-----------GVEMGNg----------qTALLKDADTVEIQt--------AATIMVRCF 131 Candida viswanathii

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