3POA,2LC1,3PO8,3OUN


Conserved Protein Domain Family
FHA_FhaA-like
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cd22668: FHA_FhaA-like 
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forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaA and similar proteins
FhaA regulates cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis. It contains an FHA domain, which is a small phosphopeptide recognition module.
Links
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Statistics
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PSSM-Id: 438720
Aligned: 11 rows
Threshold Bit Score: 120.649
Created: 4-Sep-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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phosphopeptide
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:phosphopeptide binding site [polypeptide binding site]
Evidence:
  • Structure:3POA; Mycobacterium tuberculosis FhaA in complex with a synthetic phosphopeptide, contacts at 4A
  • Structure:3OUN; Mycobacterium tuberculosis FhaA FHA domain in complex with the intracellular domain of phosphorylated pseudokinase Rv3910, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                     #                    # ####                     ##  
3POA_A          6 VTLQLDDGs-gRTYQLRe----GSNIIGRGQDA----------QFRLPDT-GVSRRHLEIRWDG--QVALLADLNSTNGT 67   Mycobacterium...
2LC1_A          9 VTLQLDDGs-gRTYQLRe----GSNIIGRGQDA----------QFRLPDT-GVSRRHLEIRWDG--QVALLADLNSTNGT 70   Mycobacterium...
3PO8_A          6 VTLQLDDGs-gRTYQLRe----GSNIIGRGQDA----------QFRLPDT-GVSRRHLEIRWDG--QVALLADLNSTNGT 67   Mycobacterium...
3OUN_A         68 VTLQLDDGs-gRTYQLRe----GSNIIGRGQDA----------QFRLPDT-GVSRRHLEIRWDG--QVALLADLNSTNGT 129  Mycobacterium...
P71590        436 VTLQLDDGs-gRTYQLRe----GSNIIGRGQDA----------QFRLPDT-GVSRRHLEIRWDG--QVALLADLNSTNGT 497  Mycobacterium...
PZR18827       46 LMLGLDDG---LVVPLGreapeGSLVIGRGEGA----------DVRLFDG-SVSSMHAEIRWDGwkRVAWLRDLGSTNGT 111  Archangium ge...
VDG61993      165 SLLLLDGSs--RTYQVHe----GSNILGRSNDA----------DFRLPDT-GVSRQHAEVIWDG--QTAFLVDLQSTNGT 225  Streptococcus...
WP_142236584  179 VTLQLDDGs-gRTYQLRe----GSNIIGRGQDA----------QFRLPDT-GVSRRHLEIRWDG--QVALLADLNSTNGT 240  Klebsiella pn...
WP_150851627  179 VNLMLQDGs-sRVYHVQe----GSNIIGRSNDA----------DLRLPDT-GVSRQHAEITWNG--QDAVLVDLQSTNGT 240  Filimonas lac...
WP_028935143 4431 AVLILRHGkhrMELPLTg----SPSTLGRNSRN----------DLVIAGDmGVSGEHAQLTWTS--GAWHLTDLESTNGT 4494 Pseudonocardi...
GEM06287        6 SYLVLLNGdgaVVKQFPrs--hGIITLGRASKNdpgtkdpsqgKFRSDNTkVMSSRHAQISWDG--DYAHITDLGSTNGV 81   Rhodotorula t...

Feature 1                                    #       #      
3POA_A         68 TVN--NAPVQ-----EWQLADGDVIRLG-------HSEIIVR 95   Mycobacterium tuberculosis
2LC1_A         71 TVN--NAPVQ-----EWQLADGDVIRLG-------HSEIIVR 98   Mycobacterium tuberculosis H37Rv
3PO8_A         68 TVN--NAPVQ-----EWQLADGDVIRLG-------HSEIIVR 95   Mycobacterium tuberculosis
3OUN_A        130 TVN--NAPVQ-----EWQLADGDVIRLG-------HSEIIVR 157  Mycobacterium tuberculosis H37Rv
P71590        498 TVN--NAPVQ-----EWQLADGDVIRLG-------HSEIIVR 525  Mycobacterium tuberculosis H37Rv
PZR18827      112 LVN--GNALTg----ELELAEGNVVTLGd-----eSAFLFLR 142  Archangium gephyra
VDG61993      226 TVN--DQLVD-----NWELADGDVITVG-------HSSIEVR 253  Streptococcus thermophilus
WP_142236584  241 TVN--NAPVQ-----EWQLADGDVIRLG-------HSEIIVR 268  Klebsiella pneumoniae
WP_150851627  241 TVN--ETPID-----NWLLADGDVITMG-------HSHIEVR 268  Filimonas lacunae
WP_028935143 4495 KVN--HERITpg--vPFRLAHGMQITVG-------TTNLFVN 4525 Pseudonocardia spinosispora
GEM06287       82 VITrdEQKVSlkpnvAYRIFERDQITFGkqvseksTGEIICR 123  Rhodotorula toruloides

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