1GXC,3I6W,3I6U


Conserved Protein Domain Family
FHA_CHK2
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cd22666: FHA_CHK2 
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forkhead associated (FHA) domain found in checkpoint kinase 2 (Chk2) and similar proteins
Chk2, also called Hucds1, Cds1 homolog, or serine/threonine-protein kinase Chk2, plays an important role in cellular responses to DNA double-strand breaks and related lesions. It is phosphorylated and activated by ATM kinase, resulting in its dissociation from sites of damage to phosphorylate downstream targets such as BRCA1, p53, cell cycle transcription factor E2F1, the promyelocytic leukemia protein (PML) involved in apoptosis, and CDC25 phosphatases, among others. Mutations in Chk2 is linked to a variety of cancers including familial breast cancer, myelodysplastic syndromes, prostate cancer, lung cancer, and osteosarcomas. Chk2 contains an N-terminal SQ/TQ cluster domain (SCD), a central forkhead-associated (FHA) domain, and a C-terminal catalytic kinase domain. The FHA domain is a small phosphopeptide recognition module.
Links
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Statistics
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PSSM-Id: 438718
Aligned: 26 rows
Threshold Bit Score: 115.415
Created: 4-Sep-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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phosphopeptide
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:phosphopeptide binding site [polypeptide binding site]
Evidence:
  • Structure:1GXC; Homo sapiens CHK2 in complex with a synthetic phosphopeptide, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                 ###                   ######           
1GXC_A        30 WARLWALQd-----------------gFANLECVnDNYWFGRDKs---CEYCFDepllkrtdkYRTYSKKHFRIFREvgp 89  human
3204496       32 WGRLYGKNikikslgtsskyriiythsSFSVDLNnDEFTAGRGEa---NDLILTlndl-pekiLTRISKVHFIIKRAnce 107 fruit fly
XP_019858435  89 WGRFFPLPra----------------gLTGIDFSdDEYIFGRSEd---CDYCFErrggtsnqhYPTYSSTHFRIYRErsk 149 Amphimedon quee...
RMX53798      59 WGRLFPLGi-----------------gFEKIDLEkDVNTFGRGTn---NDICFEprafkknpqYQAISTKHFKLYREfda 118 Pocillopora dam...
VDK24633      27 WGGLFPLKr-----------------nIPPLPMSkESYTVGREGs---CDIVLTsemfthgplLSAVSKVHFRIARVntn 86  Taenia asiatica
XP_023214969  38 WGKLFPCNs-----------------kFMSLVLTkDKYTFGRDSe---CDYCFNspqlkshssFTSLSKFHFSLIREkts 97  bark scorpion
RDD46461      26 WATFLPVGq-----------------gFSKCDLIeDTNTFGRSG----CDFCFSsdnd-knhhYRAFSKCHFNVSRErkg 83  Trichoplax sp. H2
XP_002130190  75 WGVLHSMQp-----------------eFYSLNLRdEQYTFGRANs---CDYCFDiktikstsrYKHYSKRHFAIRRVkle 134 vase tunicate
Q9U1Y5        46 FAKLVGVRr-----------------gISSIDLAdDHFVCGRGSddapTNFNFSqvak-dvglYRFISKIQFSIDRDte- 106 Caenorhabditis ...
RXG73588      39 WGRLFSTCrs---------------fkNVVIDLTeDKYTFGRGD----VTFQFTekmf-eksyLSTISKTHFLIYREyrs 98  common pillbug

Feature 1                        #                         #            
1GXC_A        90 --knsYIAYIEDHSG-NGTFVNTELVGKGKRRPLNNNSEIALSlsrnKVFVFFDL 141 human
3204496      108 ---ltNPVYIQDLSR-NGTFVNNEKIGTNRMRILKNDDVISLShptyKAFVFKDL 158 fruit fly
XP_019858435 150 tdsnqFVVFLQDKSS-NGTFINGDKIGKNKTHILNNDDEISLSvknnKVFVFNDR 203 Amphimedon queenslandica
RMX53798     119 --dgtFNVFLTDLSS-NGTFINGQKIGKNNTQPLNNNDEISLSlkkhKAYVFQNI 170 Pocillopora damicornis
VDK24633      87 ---vsPQVFIYDLST-NGTFVNGQKIGKGRMQPLCNNDEISIAtqncKCFLFTDT 137 Taenia asiatica
XP_023214969  98 ---tgIFTLLEDHSS-NGTYINGVKVGKTNKQLLTNNDEISLIvkknRAFVYMDE 148 bark scorpion
RDD46461      84 s-stgYNTFIQDMST-NGTFLNGEKIGKNQKRAIMNNDVISLAvpnnKAYVFYDI 136 Trichoplax sp. H2
XP_002130190 135 --detYQVFIEDFGGqNGVYVNGVKIPSGRKQTIKTSDEIGIAynnfNVFLFIDK 187 vase tunicate
Q9U1Y5       107 ----tRRIYLHDHSR-NGTLVNQEMIGKGLSRELMNGDLISIGipalIIFVYESA 156 Caenorhabditis elegans
RXG73588      99 --gcdPIVVLEDRSQ-NGTFVNKSLVGKYKKKLLRNNDEISLAlpsrRVFVFYDC 150 common pillbug

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