Conserved Protein Domain Family
NTD_gammaCoV_Nsp15-like
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cd22650: NTD_gammaCoV_Nsp15-like 
N-terminal domain of gammacoronavirus Nonstructural protein 15 (Nsp15), and related proteins
Coronavirus (CoV) Nsp15 is a nidovirus endoribonuclease (NendoU). NendoUs are uridylate-specific endoribonucleases, which release a cleavage product containing a 2',3'-cyclic phosphate at the 3' terminal end. NendoUs include coronavirus Nsp15 and arterivirus Nsp11, both of which may participate in the viral replication process and in the evasion of the host immune system. This NTD structure (approximately 60 residues) present in coronavirus Nsp15, is missing in Nsp11. CoV Nsp15 has an N-terminal domain, a middle (M) domain, and a C-terminal catalytic (NendoU) domain. Nsp15 from alpha- and betaCoVs such as Severe Acute Respiratory Syndrome (SARS)-CoV, human Coronavirus 229E (HCoV229E), and Murine Hepatitis Virus (MHV) form a functional hexamer. The active form of the Nsp15 of Turkey CoV (TCoV), a gammaCoV, has been reported to be a homohexamer. Residues in this N-terminal domain may be important for hexamer formation.
Links
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Statistics
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PSSM-Id: 439165
Aligned: 23 rows
Threshold Bit Score: 114.577
Created: 22-Oct-2020
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative trimerputative
Feature 1:putative trimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the structures of SARS-CoV (a betaCoV) and human CoV 229E (an alphaCoV) Nsp15 that function as hexamers (dimer of trimers)
  • Comment:Not all coronavirus Nsp15 form hexamers; Porcine DeltaCoronavirus (PDCoV) Nsp15 has been shown to exist as dimers and monomers in solution.
  • Comment:The active form of the Nsp15 of Turkey CoV (TCoV), a gammaCoV, has been reported to be a homohexamer.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ### ##            #### #  # ######  ####            #
P0C6Y2    5991 IDNIAYNMYKgGHYDAIAGEMPTVITGDKVFVIDQGVEKAVFVNQTTLPTSVAFELYAKR 6050 Avian infectious bronchitis virus (s...
ABW81426  5989 IDNIAYNMYKgGHYDAIAGEMPTIVTGDKVFVIDQGVERAVFVNQTTLPTSVAFELYAKR 6048 Turkey coronavirus
AKF17722  6035 IDNIAYNMYKrGHYDAVVGEIPTVVTGDKVFVIDKGIEKAVFVNQSTLPTSVAFELFAKR 6094 Duck coronavirus
QAT77247  2015 IENIAYNMYKgGHYDAIAGEMPTIVTGDKVFVIDQGVEKAVFINQTTLPTSVAFELYAKR 2074 Infectious bronchitis virus
QGM12376  6001 IDNIAYNMYKgGHYDAIAGEMPTIVTGDKVFVIDQGVEKAVFVNRTTLPTSVAFELYAKR 6060 Infectious bronchitis virus
APP92727  5990 IDNIAYNMYKgGHYDAVAGEMPTVVTGDKVFVIDQGVEKAVFVNQTTLPTSVAFELYAKR 6049 Infectious bronchitis virus
AKV63203  5993 IDNIAYNMYKrGHYDAIAGEMPIIVTGNKVFVIGQGVEKAVFVNQTILPTSVAFELYGKR 6052 Infectious bronchitis virus
QDY92334  6013 IDNIAYNMYKrGHYDAVVGEIPTVVTGDKVFVIDQGVEKAVFVNQSTLPTSVAFELFAKR 6072 Avian coronavirus
AKQ98491     1 IDNIAYNMYKrGHYDAVVGEMPTIVTGDKVFVIDKGVEKAVFVNQSTLPTSVAFELYAKR 60   Pigeon-dominant Coronavirus
P0C6Y3    5993 IDNIAYNMYKgGHYDAIAGEMPTIVTGDKVFVIDQGVEKAVFFNQTILPTSVAFELYAKR 6052 Avian infectious bronchitis virus (s...

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