6XYB,6XYD


Conserved Protein Domain Family
Q4D6Q6-like
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cd22648: Q4D6Q6-like 
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Q4D6Q6-like domain family
This family includes Trypanosoma cruzi protein Q4D6Q6 and similar proteins. Q4D6Q6 is a conserved and kinetoplastid-specific protein essential for cell viability. Its monomers adopt a beta-beta-alpha-beta-beta-alpha-beta-beta topology and form a propeller-like tetramer. An oxidized cysteine, which is part of a cluster with phosphorylated serines and hydrophobic residues, has been identified as a highly reactive site, and may play a role as a nucleophile in a post-translational modification reaction. Since Q4D6Q6 is not present in mammals, it can be a potential drug target against kinetoplastid infection causing Chagas disease, Sleeping sickness and Leishmaniasis.
Links
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Statistics
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PSSM-Id: 439353
Aligned: 22 rows
Threshold Bit Score: 152.04
Created: 13-Oct-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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tetramerion binding
Conserved site includes 35 residues -Click on image for an interactive view with Cn3D
Feature 1:tetramer interface [polypeptide binding site]
Evidence:
  • Structure:6XYB; Trypanosoma cruzi kinetoplastid-specific protein Q4D6Q6 forms a homotetramer, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ##### #          ##                                              # #            
6XYB_A         4 MPNLCVSATFNPPVITMLGsalrEETVKLLEQRIPTGVSTsssp----skdPVKFLFYPN-----PDHWRMELSQHF-XD 73  Trypanosoma cru...
XP_011771702   1 MPVIVVNLVFNPPEVSLIGkglsTSIMNRLESELIVRTTTsrpvtasmgteGPLFVQNPNgcsagAEVWRLTIPNHY-CD 79  Trypanosoma bru...
XP_003860178   3 EMNLIVNITCNPPVISIFGpi-kESTIDRLNETIPNSCSTtnt-----gktPFALVRKDD-----PPHWFGELRTQFaTE 71  Leishmania dono...
XP_011778531   2 SHYLLVTFTFNCPEIRILGpi-kEQTIEKLNDVIPNATTTsrsn----rtaLPKFEYLPN-----PNHWYIKLDRQF-CD 70  Trypanosoma bru...
XP_003863890   2 SRNMIVNMSFNCPEIQILGpv-qESTIERLNEVLPDSTTStrsi----rsnQPKFEYLSN-----PDHWRIKLDNQF-CD 70  Leishmania dono...
CCW63077       2 SNTLVINLSFNCPVVDIIGpi-kETTIERLNELLPTSTTStrnc----rseAPKFQYLSN-----PDHWHLKLDGQL-CD 70  Phytomonas sp. ...
CUF39609       5 DQNLIINVTVNPPEISIVGpi-kENTIQKLNTILPTVCTTtnt-----aktKFAFNRVEN-----PPHWSGKLSTHFaNE 73  Bodo saltans
EPY26449       2 EKTLIVNLTFNCPEISIVGpi-kESTIDVLNELIPYSTTSafcs----nptKAKFRHVKN-----PSHWSIKLDGQF-CD 70  Angomonas deanei
PBJ71552       1 MPNVIVNCTFNPPAFSVTGtqlrQETLDSLEKVLPQCTTTsqnsmgaangnAPKFMLVNSq----PNTWRMSIGQHY-CD 75  Trypanosoma cru...
XP_028879034   1 MPYVIVNCTFNPPTLSITGaqlrQETIDSLEKSIPQCTTTssssn-smngtTAKFTLSESq----PQTWHMSIGQQY-CD 74  Trypanosoma the...

Feature 1        ### ## ##  ##  #     ###########           ### # 
6XYB_A        74 DLHKSAVFLTIIEGLEGEG-WNLRASNSIRDSe------sGKDTTKLFF 115 Trypanosoma cruzi strain CL Brener
XP_011771702  80 DLAKCAFFGSVISVMEGDG-WSLVCSSATTTSg------dGKEISRFFF 121 Trypanosoma brucei gambiense DAL972
XP_003860178  72 DIGTSMLFISVLDALEEEGvWKLRGSTSLSHDc-------NKTTYKFFF 113 Leishmania donovani
XP_011778531  71 EDGKSHLMVLLLDALSEEGsWRLVSSFVTKEPsgtg-skeGTETHTLFL 118 Trypanosoma brucei gambiense DAL972
XP_003863890  71 LEGVSRLIVLLLDALEEEGgWTLISSQASSSShggalqqdFVSNYKLFF 119 Leishmania donovani
CCW63077      71 SEGVSHFIVVLLDVLEQEGgWTLVSSQASNSDnagaiqqkYVENYKLFF 119 Phytomonas sp. isolate EM1
CUF39609      74 EIGQAQLFVTMLDALEEEGgWKLKGSNATNHDv-------DKVTYKFFF 115 Bodo saltans
EPY26449      71 SEGISRLMVILMDALDEEGgWTLVSSQSYNVRssvplqqnYVENHKMIF 119 Angomonas deanei
PBJ71552      76 QRGRCVVFSTIISTLQTEG-WTLRTTDSHESDn-------GKDITRLFF 116 Trypanosoma cruzi cruzi
XP_028879034  75 QRGRCVVFAAVAQALQLEG-WALRTTDAVSWEn-------EKDVTRLFF 115 Trypanosoma theileri

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